(R)-6-(3-Methylpiperazin-1-yl)nicotinonitrile

Name: (R)-6-(3-Methylpiperazin-1-yl)nicotinonitrile
Brand: ChemScene
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CAS No. 1057682-05-9
Cat. No. CS-0158233
Molecule weight202.26
Purity≥97%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
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(R)-6-(3-Methylpiperazin-1-yl)nicotinonitrile|CS-0158233

Structure of 1057682-05-9

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General Information

CAS No. 1057682-05-9
Cat. No. CS-0158233
Purity ≥97%
MDL No. None
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₁H₁₄N₄
Molecular Weight 202.26
Synonym(s) 6-[(3R)-3-Methyl-1-piperazinyl]-3-pyridinecarbonitrile
SMILES C[C@@H]1CN(CCN1)C2=NC=C(C=C2)C#N

Description

(R)-6-(3-Methylpiperazin-1-yl)nicotinonitrile is a chiral heterocyclic building block featuring a nitrile group at the 6-position of a nicotinamide scaffold. The (R)-configured piperazine moiety imparts distinct stereochemical properties, enabling selective interactions in medicinal chemistry applications. This compound demonstrates enhanced solubility and stability under standard bench conditions, facilitating its integration into complex molecular architectures.

Application

(R)-6-(3-Methylpiperazin-1-yl)nicotinonitrile serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles through standard coupling and cyclization protocols. Its nitrile group offers orthogonal reactivity for amide formation or hydrolysis, while the chiral piperazine moiety enhances solubility and pharmacophore diversity. Bench-stable and compatible with common reaction conditions, it facilitates efficient synthesis of targeted scaffolds in drug discovery workflows.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 51.95
LogP 0.75138
H_Acceptors 4
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Building Blocks Skeleton Aliphatic heterocycle compounds Piperazine compounds

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

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(R)-6-(3-Methylpiperazin-1-yl)nicotinonitrile

CAS No. 1057682-05-9

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