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CS-W001157 4
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7-Ethynyl-1h-indole

  • CAS No. 1057670-22-0

  • Cat. No. CS-0266224
  • Molecule weight141.17
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

7-Ethynyl-1h-indole|CS-0266224

Structure of 1057670-22-0

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General Information

  • CAS No. 1057670-22-0
  • Cat. No. CS-0266224
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₇N
  • Molecular Weight 141.17
  • Synonym(s) None
  • SMILES C#CC1=CC=CC2=C1NC=C2

Description

7-Ethynyl-1H-indole delivers a reactive alkyne handle for copper-catalyzed azide-alkyne cycloaddition (CuAAC), enabling efficient conjugation in bioorthogonal labeling and probe synthesis. This bench-stable, electron-rich heterocycle integrates seamlessly into molecular architectures requiring precise spatial control and minimal steric interference.

Application

7-Ethynyl-1H-indole serves as a versatile building block in transition-metal-catalyzed coupling reactions, enabling efficient access to conjugated indole derivatives. Its terminal alkyne functionality facilitates reliable Sonogashira and Glaser-type couplings, offering high functional group tolerance and bench stability. The molecule functions as a key scaffold for constructing biologically relevant heterocycles and extended π-systems in medicinal chemistry and materials science applications.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   15.79
  • LogP   2.1492
  • H_Acceptors   0
  • H_Donors   1
  • Rotatable_Bonds   0

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