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CS-W001157 4
Total: USD 88.00

Tr-PEG2-OH

  • CAS No. 105589-77-3

  • Cat. No. CS-0064745
  • Purity≥98%
  • MDL No.MFCD17926568

*For research and further manufacturing use only, not for direct human use.

Tr-PEG2-OH|CS-0064745

Structure of 105589-77-3

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General Information

  • CAS No. 105589-77-3
  • Cat. No. CS-0064745
  • Purity ≥98%
  • MDL No. MFCD17926568
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₃H₂₄O₃
  • Molecular Weight 348.43
  • Synonym(s) None
  • SMILES OCCOCCOC(C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3

Description

Tr-PEG2-OH features a triarylborane moiety linked to a short polyethylene glycol chain terminating in a hydroxyl group. This structure combines boron-based reactivity with PEG-mediated solubility and stability, enabling efficient conjugation in aqueous environments. The hydroxyl terminus supports further derivatization, while the PEG spacer reduces aggregation and enhances biocompatibility.

Application

Tr-PEG2-OH serves as a versatile bifunctional building block for conjugation and polymer synthesis, combining the robust stability of trialkylsilyl protection with the solubility and flexibility of a short PEG chain. The terminal hydroxyl group enables reliable coupling reactions, while the silyl-protected form ensures excellent bench stability and compatibility with moisture-sensitive transformations. Widely used in peptide modification and drug delivery systems, it facilitates efficient functionalization under standard conditions.

Synthesis

  • Route1
    • null|null
      76-83-5
    • In-stock
      Diethylene glycol|CS-0014055
      111-46-6
    • ~82%
    • In-stock
      Tr-PEG2-OH|CS-0064745
      105589-77-3

    References

    • Gothard, Chris M.; Grzybowski, Bartosz A. Synthesis, 2012 , vol. 44, # 5 p. 717 - 722
  • Route2
    • null|null
      76-83-5
    • ~%
    • In-stock
      Tr-PEG2-OH|CS-0064745
      105589-77-3

    References

    • Fordyce; Lovell; Hibbert Journal of the American Chemical Society, 1939 , vol. 61, p. 1905,1908
  • Route3

    References

    • Altenburger, Jean-Michel; Lebeau, Luc; Mioskowski, Charles; Schirlin, Daniel Helvetica Chimica Acta, 1992 , vol. 75, # 8 p. 2538 - 2544

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   38.69
  • LogP   4.004
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   9

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