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CS-W001157 4
Total: USD 88.00

DOTMA

  • CAS No. 104872-42-6

  • Cat. No. CS-0181859
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

DOTMA|CS-0181859

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General Information

  • CAS No. 104872-42-6
  • Cat. No. CS-0181859
  • Purity ≥98%
  • MDL No. None
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄₂H₈₄ClNO₂
  • Molecular Weight 670.57
  • Synonym(s) None
  • SMILES CCCCCCCC/C=C/CCCCCCCCOCC(C[N+](C)(C)C)OCCCCCCCC/C=C/CCCCCCCC.[Cl-]

Description

Inducing positive surface charge on liposomal formulations, DOTMA (CAS 104872-42-6) enhances electrostatic engagement with anionic cell membranes to drive efficient in vitro and in vivo gene delivery via siRNA, microRNA, and oligonucleotide encapsulation.

Application

DOTMA (CAS 104872-42-6) drives the construction of miRNA delivery systems by serving as a critical lipid-based building block in non-viral gene delivery platforms. It enables efficient cellular uptake. Researchers leverage this to enhance silencing efficacy in targeted RNA interference applications.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P305+P351+P338-P362+P364

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Computational Chemistry Data

  • TPSA   18.46
  • LogP   10.1734
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   37

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