(2-Chloropyrimidin-5-yl)methanol

Name: (2-Chloropyrimidin-5-yl)methanol
Brand: ChemScene
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CAS No. 1046816-75-4
Cat. No. CS-W020676
Purity≥98%
MDL No.MFCD16659172

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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(2-Chloropyrimidin-5-yl)methanol|CS-W020676

Structure of 1046816-75-4

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General Information

CAS No. 1046816-75-4
Cat. No. CS-W020676
Purity ≥98%
MDL No. MFCD16659172
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₅ClN₂O
Molecular Weight 144.56
Synonym(s) 2-Chloro-5-pyrimidinemethanol; 2-Chloro-5-(hydroxymethyl)pyrimidine
SMILES OCC1=CN=C(Cl)N=C1

Description

2-Chloro-5-pyrimidinemethanol features a chlorinated pyrimidine core with a reactive hydroxymethyl group, enabling direct functionalization in nucleoside analog synthesis. The molecule exhibits enhanced stability under standard bench conditions and facilitates efficient coupling reactions in medicinal chemistry workflows.

Application

2-Chloro-5-pyrimidinemethanol serves as a versatile building block in medicinal chemistry, enabling efficient access to pyrimidine-based scaffolds. Its chloro group facilitates nucleophilic substitution reactions, while the pendant hydroxymethyl functionality supports derivatization via etherification or oxidation. The compound exhibits good bench stability and is compatible with standard coupling protocols, making it well-suited for modular synthesis of heterocyclic intermediates and API candidates.

Synthesis

Route1
- In-stock
  
  287714-35-6
- ~%
- In-stock
  
  1046816-75-4
References
- PROSIDION LIMITED; BARBA, Oscar; BELL, James, Charles; DUPREE, Tom, Banksia; FRY, Peter, Timothy; BERTRAM, Lisa, Sarah; FYFE, Matthew, Colin, Thor; GATTRELL, William; JEEVARATNAM, Revathy, Perpetua; KEILY, John; KRULLE, Thomas, Martin; MCDONALD, Russell, Walker; MORGAN, Trevor; RASAMISON, Chrystelle, Marie; SCHOFIELD, Karen, Lesley; STEWART, Alan, John, William; SWAIN, Simon, Andrew; WITHALL, David, Matthew Patent: WO2011/147951 A1, 2011 ; Location in patent: Page/Page column 57; 58 ; WO 2011/147951 A1
Route2
- In-stock
  
  120747-85-5
- ~%
- In-stock
  
  1046816-75-4
References
- Genelabs Technologies, Inc. Patent: US2009/226398 A1, 2009 ;

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 46.01
LogP 0.6223
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Pyrimidine compounds

Key Words

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(2-Chloropyrimidin-5-yl)methanol

CAS No. 1046816-75-4

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