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CS-W001157 4
Total: USD 88.00

1-Bromo-3-(bromomethyl)-2-chlorobenzene

  • CAS No. 1044256-89-4

  • Cat. No. CS-0696205
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

1-Bromo-3-(bromomethyl)-2-chlorobenzene|CS-0696205

Structure of 1044256-89-4

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General Information

  • CAS No. 1044256-89-4
  • Cat. No. CS-0696205
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₅Br₂Cl
  • Molecular Weight 284.38
  • Synonym(s) None
  • SMILES ClC1=C(Br)C=CC=C1CBr

Description

1-Bromo-3-(bromomethyl)-2-chlorobenzene features a bromomethyl group flanked by bromo and chloro substituents on a benzene ring, enabling orthogonal reactivity in multi-step synthesis. This arrangement supports selective functionalization under mild conditions, particularly in cross-coupling and nucleophilic substitution processes. The molecule’s steric and electronic profile facilitates controlled transformations without significant side reactions.

Application

1-Bromo-3-(bromomethyl)-2-chlorobenzene serves as a versatile dihalogenated aromatic building block, enabling efficient construction of complex pharmaceutical intermediates. The bromomethyl group facilitates nucleophilic substitution and coupling reactions, while the ortho-bromo and meta-chloro substituents provide orthogonal reactivity for sequential functionalization. Bench-stable and compatible with standard cross-coupling protocols, it functions reliably in the synthesis of heterocyclic scaffolds and bioactive molecules.

Safety Information

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GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 1759
Class : 8
Packing Group : Ⅲ
Hazard Statements : H302-H314
Precautionary Statements : P260-P264-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P363-P405-P501

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Computational Chemistry Data

  • TPSA   0
  • LogP   3.9974
  • H_Acceptors   0
  • H_Donors   0
  • Rotatable_Bonds   1

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