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CS-W001157 4
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N-Methylsulfamoyl chloride

  • CAS No. 10438-96-7

  • Cat. No. CS-0150984
  • Purity≥97%
  • MDL No.MFCD00126938

*For research and further manufacturing use only, not for direct human use.

N-Methylsulfamoyl chloride|CS-0150984

Structure of 10438-96-7

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General Information

  • CAS No. 10438-96-7
  • Cat. No. CS-0150984
  • Purity ≥97%
  • MDL No. MFCD00126938
  • Storage 4°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula CH₄ClNO₂S
  • Molecular Weight 129.57
  • Synonym(s) Methylsulfamoyl chloride
  • SMILES CNS(=O)(=O)Cl

Description

N-Methylsulfamoyl chloride features a reactive sulfonyl chloride group paired with a methyl-substituted nitrogen, enabling efficient incorporation into pharmaceutical intermediates. This bench-stable reagent facilitates rapid amide bond formation and sulfonamide synthesis under mild conditions, offering high functional group tolerance and clean reaction profiles.

Application

N-Methylsulfamoyl chloride serves as a versatile acylating agent for the direct introduction of the sulfamoyl group into organic substrates. It facilitates efficient amide bond formation with amines under mild conditions, offering high functional group tolerance and ease of handling in synthetic workflows. Its bench stability and clean reaction profile make it a practical choice for building sulfonamide-containing scaffolds in medicinal chemistry and process development.

Synthesis

  • Route1
    • Methylsulfamic Acid|CS-0622168
      4112-03-2
    • ~70%
    • In-stock
      N-Methylsulfamoyl chloride|CS-0150984
      10438-96-7

    References

    • US2012/214803 A1, ; Page/Page column 158 ; US 20120214803 A1
  • Route2
    • null|null
      593-51-1
    • ~64%
    • In-stock
      N-Methylsulfamoyl chloride|CS-0150984
      10438-96-7

    References

    • Chemische Berichte, , vol. 114, # 2 p. 774 - 786
  • Route3
    • null|null
      74-89-5
    • ~%
    • In-stock
      N-Methylsulfamoyl chloride|CS-0150984
      10438-96-7

    References

    • Justus Liebigs Annalen der Chemie, , vol. 729, p. 40 - 51

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 1760
Class : 8
Packing Group : Ⅲ
Hazard Statements : H302-H312-H314-H332
Precautionary Statements : P260-P261-P264-P270-P271-P280-P301+P330+P331-P304+P340-P363-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   46.17
  • LogP   -0.3106
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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