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CS-W001157 4
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2-Bromo-2-methyl-1-phenylpropan-1-one

  • CAS No. 10409-54-8

  • Cat. No. CS-0379375
  • Purity≥96%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-Bromo-2-methyl-1-phenylpropan-1-one|CS-0379375

Structure of 10409-54-8

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General Information

  • CAS No. 10409-54-8
  • Cat. No. CS-0379375
  • Purity ≥96%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₁BrO
  • Molecular Weight 227.10
  • Synonym(s) α-Bromoisobutyrophenone
  • SMILES O=C(C(C)(C)Br)C1=CC=CC=C1

Description

2-Bromo-2-methyl-1-phenylpropan-1-one features a brominated ketone scaffold that enables direct incorporation into C–C bond formation strategies. The α-bromoketone functionality supports nucleophilic substitution and enolate chemistry under mild conditions, offering reliable access to complex alkylated derivatives in synthetic organic workflows.

Application

2-Bromo-2-methyl-1-phenylpropan-1-one serves as a versatile building block in synthetic organic chemistry, enabling efficient access to quaternary carbon centers via nucleophilic substitution or conjugate addition. Its α-bromoketone functionality facilitates C–C bond formation under mild conditions, with high bench stability and compatibility across diverse reaction environments. The molecule functions effectively in the synthesis of complex heterocycles and pharmaceutical intermediates, offering predictable reactivity and straightforward purification.

Synthesis

  • Route1

    References

    • Canadian Journal of Chemistry, , vol. 62, p. 1646 - 1652
  • Route2
    • null|null
      538-93-2
    • ~57%
    • In-stock
      2-Bromo-2-methyl-1-phenylpropan-1-one|CS-0379375
      10409-54-8

    References

    • Organic and Biomolecular Chemistry, , vol. 8, # 20 p. 4701 - 4704
  • Route3
    • null|null
      39753-69-0
    • ~98%
    • In-stock
      2-Bromo-2-methyl-1-phenylpropan-1-one|CS-0379375
      10409-54-8

    References

    • Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), , vol. 30, # 7 p. 1275 - 1279 Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, , # 7 p. 1581 - 1586

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   17.07
  • LogP   3.0428
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   2

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