4-Chloro-N-methylbenzylamine

Name: 4-Chloro-N-methylbenzylamine
Brand: ChemScene
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CAS No. 104-11-0
Cat. No. CS-W002118
Purity≥95%
MDL No.MFCD00018749

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Description

4-Chloro-N-methylbenzylamine features a para-chlorinated benzyl scaffold with a tertiary amine handle, enabling direct incorporation into pharmaceutical intermediates. The electron-withdrawing chlorine substituent enhances electrophilic reactivity at the aromatic ring while the N-methyl group improves metabolic stability and solubility in organic media. This bifunctional architecture supports efficient coupling reactions under mild conditions.

Application

4-Chloro-N-methylbenzylamine serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles and pharmaceutical intermediates. Its benzylic amine functionality exhibits excellent reactivity in coupling and cyclization reactions, while the ortho-chloro substituent provides a handle for further derivatization via palladium-catalyzed cross-coupling. The N-methyl group enhances metabolic stability and modulates basicity, improving membrane permeability. Bench-stable and readily purified by distillation or chromatography, it functions efficiently in standard synthetic workflows.

General Information

CAS No. 104-11-0
Cat. No. CS-W002118
Purity ≥95%
MDL No. MFCD00018749
Storage RT, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₈H₁₀ClN
Molecular Weight 155.63
Synonym(s) P-CHLORO-N-METHYLBENZYLAMINE
SMILES CNCC1=CC=C(Cl)C=C1

Computational Chemistry Data

TPSA 12.03
LogP 2.0594
H_Acceptors 1
H_Donors 1
Rotatable_Bonds 2

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS05
Signal Word : Danger	UN#: 2735
Class : 8	Packing Group : Ⅲ
Hazard Statements : H314-H318
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

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4-Chloro-N-methylbenzylamine

CAS No. 104-11-0

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