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2,2-Dimethyl-3-(m-tolyl)propan-1-ol

  • CAS No. 103694-68-4

  • Cat. No. CS-0153220
  • Molecule weight178.27
  • Purity≥98%
  • MDL No.MFCD03701092

*For research and further manufacturing use only, not for direct human use.

2,2-Dimethyl-3-(m-tolyl)propan-1-ol|CS-0153220

Structure of 103694-68-4

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General Information

  • CAS No. 103694-68-4
  • Cat. No. CS-0153220
  • Purity ≥98%
  • MDL No. MFCD03701092
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₈O
  • Molecular Weight 178.27
  • Synonym(s) Majantol
  • SMILES CC1=CC(=CC=C1)CC(C)(C)CO

Description

This bench-stable tertiary alcohol features a sterically hindered dimethyl-substituted backbone paired with a meta-tolyl aromatic group, enabling reliable integration into complex synthetic sequences. The structure resists oxidation and dehydration under standard conditions, delivering consistent performance in asymmetric synthesis and polymerizable monomer design.

Application

2,2-Dimethyl-3-(m-tolyl)propan-1-ol serves as a robust chiral building block in synthetic organic chemistry, enabling efficient construction of sterically hindered aryl-alcohol motifs. Its bench-stable tertiary alcohol functionality exhibits excellent functional group tolerance and facilitates downstream transformations such as oxidation to ketones or conversion to esters and ethers. The m-tolyl substituent provides enhanced lipophilicity and structural rigidity, making it valuable for medicinal chemistry campaigns targeting CNS-penetrant scaffolds and kinase inhibitors.

Synthesis

  • Route1
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      107737-97-3
    • ~%
    • In-stock
      2,2-Dimethyl-3-(m-tolyl)propan-1-ol|CS-0153220
      103694-68-4

    References

    • US4710316 A1, ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H412
Precautionary Statements : P264-P270-P273-P330-P501

Quality Control

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Computational Chemistry Data

  • TPSA   20.23
  • LogP   2.55602
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   3

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