5’-O-(4,4’-Dimethoxytrityl)-2’-O-methyluridine

Name: 5’-O-(4,4’-Dimethoxytrityl)-2’-O-methyluridine
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 103285-22-9
Cat. No. CS-0061965
Purity≥95%
MDL No.MFCD00274123

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

5’-O-(4,4’-Dimethoxytrityl)-2’-O-methyluridine|CS-0061965

Structure of 103285-22-9

Size

Price

Quantity

* Please select Quantity before adding items.

Description

5’-O-(4,4’-Dimethoxytrityl)-2’-O-methyluridine delivers a protected nucleoside scaffold for automated oligonucleotide synthesis. The dimethoxytrityl group enables efficient 5’-end labeling and chain elongation, while the 2’-O-methyl modification enhances nuclease resistance and conformational stability in synthetic RNA analogs. This derivative supports high-fidelity incorporation under standard phosphoramidite coupling conditions.

Application

5’-O-(4,4’-Dimethoxytrityl)-2’-O-methyluridine serves as a key building block in the synthesis of modified oligonucleotides, enabling efficient 3’→5’ phosphodiester linkage formation. The 4,4’-dimethoxytrityl group provides robust protection at the 5’-hydroxyl, facilitating controlled chain elongation and ease of purification via trityl cation monitoring. The 2’-O-methyl modification enhances nuclease resistance and improves binding affinity, making this derivative ideal for antisense and RNAi applications requiring enhanced stability and target specificity.

General Information

CAS No. 103285-22-9
Cat. No. CS-0061965
Purity ≥95%
MDL No. MFCD00274123
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₃₁H₃₂N₂O₈
Molecular Weight 560.59
Synonym(s) None
SMILES O[C@H]1[C@@H](OC)[C@H](N2C(NC(C=C2)=O)=O)O[C@@H]1COC(C3=CC=C(OC)C=C3)(C4=CC=CC=C4)C5=CC=C(OC)C=C5

Computational Chemistry Data

TPSA 121.24
LogP 2.8358
H_Acceptors 9
H_Donors 2
Rotatable_Bonds 10

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Other Classifications

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Life Science Nucleosides & Nucleotides 2'-O-MOE-modified Nucleoside

Chemical Biology Nucleic Acid Chemistry Methylated Nucleosides

Biochemistry Biochemicals and Reagents Nucleosides, Nucleotides, Oligonucleotides Nucleobases and their Analogs

Biochemistry Biochemicals and Reagents Nucleosides, Nucleotides, Oligonucleotides Nucleoside Analogs

Key Words

103285-22-9 sigma103285-22-9 manufacturer103285-22-9 price103285-22-9 structure103285-22-9 SDSbuy 103285-22-9103285-22-9 supplier103285-22-9 uses103285-22-9 molecular weightprice of 103285-22-9103285-22-9 chemical name formula of 103285-22-9

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

5’-O-(4,4’-Dimethoxytrityl)-2’-O-methyluridine

CAS No. 103285-22-9

Recommended Products