Lot numbers can be found on the outside label of a product:
N-Methylisatoic anhydride
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CAS No. 10328-92-4
- Cat. No. CS-0008011
- Purity≥97%
- MDL No.MFCD00006815
*For research and further manufacturing use only, not for direct human use.
Structure of 10328-92-4
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General Information
- CAS No. 10328-92-4
- Cat. No. CS-0008011
- Purity ≥97%
- MDL No. MFCD00006815
- Storage 4°C
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₉H₇NO₃
- Molecular Weight 177.16
- Synonym(s) None
- SMILES O=C(OC1=O)N(C)C2=C1C=CC=C2
Description
N-Methylisatoic anhydride delivers a reactive, bench-stable platform for amide bond formation in synthetic chemistry. Featuring a sterically accessible anhydride moiety paired with a methyl-substituted isatoic scaffold, it facilitates efficient coupling under mild conditions. This derivative enables direct incorporation into peptide and small-molecule architectures without requiring pre-activation.
Application
N-Methylisatoic anhydride serves as a versatile building block in synthetic organic chemistry, enabling efficient access to substituted isoindolinones and related heterocyclic scaffolds. Its reactive anhydride functionality facilitates nucleophilic acylation under mild conditions, offering high functional group tolerance and excellent bench stability. The molecule functions as a key intermediate in the synthesis of pharmaceutical candidates and advanced materials, particularly where ortho-acylation and cyclization sequences are required.
Synthesis
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Route1
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In-stock
118-48-9 -
74-88-4 - ~87%
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In-stock
10328-92-4
References
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Journal of Medicinal Chemistry, , vol. 55, # 17 p. 7593 - 7613
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Route2
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201230-82-2
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100-61-8
- ~84%
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In-stock
10328-92-4
References
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Journal of the American Chemical Society, , vol. 134, # 42 p. 17490 - 17493,4
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Route3
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In-stock
118-48-9
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77-78-1
- ~%
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In-stock
10328-92-4
References
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WO2010/70449 A2, ; Page/Page column 26 ;
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319-H335
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Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 52.21
- LogP 0.4917
- H_Acceptors 4
- H_Donors 0
- Rotatable_Bonds 0
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Key Words
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