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CS-W001157 4
Total: USD 88.00

2-Methoxy-4-(trifluoromethyl)phenol

  • CAS No. 1027888-79-4

  • Cat. No. CS-0163522
  • Purity≥98%
  • MDL No.MFCD13185693

*For research and further manufacturing use only, not for direct human use.

2-Methoxy-4-(trifluoromethyl)phenol|CS-0163522

Structure of 1027888-79-4

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General Information

  • CAS No. 1027888-79-4
  • Cat. No. CS-0163522
  • Purity ≥98%
  • MDL No. MFCD13185693
  • Storage RT, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₇F₃O₂
  • Molecular Weight 192.14
  • Synonym(s) 4-Hydroxy-3-methoxybenzotrifluoride
  • SMILES OC1=CC=C(C(F)(F)F)C=C1OC

Description

2-Methoxy-4-(trifluoromethyl)phenol features a trifluoromethyl group that imparts strong electron-withdrawing character and enhanced metabolic stability, while the methoxy substituent contributes to solubility and regioselective reactivity. This combination enables efficient incorporation into pharmaceutical intermediates and agrochemical scaffolds under standard conditions.

Application

2-Methoxy-4-(trifluoromethyl)phenol serves as a versatile building block in medicinal chemistry and agrochemical synthesis, offering a trifluoromethyl group for enhanced metabolic stability and lipophilicity. The phenolic hydroxyl enables direct functionalization or derivatization, while the methoxy substituent provides steric and electronic modulation. Its bench-stable nature facilitates straightforward handling and purification in multi-step syntheses.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   29.46
  • LogP   2.4196
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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