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CS-W001157 4
Total: USD 88.00

3-Chloro-5-methoxyaniline

  • CAS No. 10272-06-7

  • Cat. No. CS-0061958
  • Purity≥98%
  • MDL No.MFCD11035922

*For research and further manufacturing use only, not for direct human use.

3-Chloro-5-methoxyaniline|CS-0061958

Structure of 10272-06-7

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General Information

  • CAS No. 10272-06-7
  • Cat. No. CS-0061958
  • Purity ≥98%
  • MDL No. MFCD11035922
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₈ClNO
  • Molecular Weight 157.60
  • Synonym(s) None
  • SMILES COC1=CC(=CC(=C1)N)Cl

Description

3-Chloro-5-methoxyaniline features a chlorinated aromatic ring paired with electron-donating methoxy and amino groups, enabling selective coupling in pharmaceutical intermediates. This bench-stable derivative offers enhanced solubility and reactivity in amine-directed transformations under standard conditions.

Application

3-Chloro-5-methoxyaniline serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling efficient access to substituted anilines via palladium-catalyzed cross-coupling reactions. Its ortho-chloro and meta-methoxy substituents provide predictable regioselectivity and enhanced functional group tolerance, facilitating downstream derivatization. The compound exhibits excellent bench stability and ease of purification, making it well-suited for high-throughput screening campaigns and process-scale applications.

Synthesis

  • Route1

    References

    • Journal of the Chemical Society, , p. 2078

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   35.25
  • LogP   1.9308
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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