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CS-W001157 4
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4-Methylnaphthalen-1-ol

  • CAS No. 10240-08-1

  • Cat. No. CS-0444441
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

4-Methylnaphthalen-1-ol|CS-0444441

Structure of 10240-08-1

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General Information

  • CAS No. 10240-08-1
  • Cat. No. CS-0444441
  • Purity ≥98%
  • MDL No. None
  • Storage RT, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₀O
  • Molecular Weight 158.20
  • Synonym(s) 4-Methyl-1-naphthol
  • SMILES C1=2C(C(C)=CC=C1O)=CC=CC2

Description

4-Methylnaphthalen-1-ol features a naphthalene core with a hydroxyl group at position 1 and a methyl substituent at position 4, delivering enhanced solubility and stability compared to unsubstituted analogs. This scaffold integrates readily into synthetic routes requiring electron-rich aromatic systems, particularly in pharmaceutical intermediates and advanced materials.

Application

4-Methylnaphthalen-1-ol serves as a versatile building block in synthetic organic chemistry, enabling efficient access to substituted naphthalene scaffolds. Its phenolic functionality facilitates electrophilic substitution, Suzuki coupling, and direct arylation reactions under standard conditions. The methyl group provides a site for oxidation or functionalization, enhancing structural diversity. Bench-stable and readily purified by recrystallization, it functions reliably in multi-step syntheses targeting advanced intermediates for pharmaceutical and materials applications.

Synthesis

  • Route1

    References

    • Springer,J.M. et al. Journal of Organic Chemistry, 1971 , vol. 36, p. 686 - 689
  • Route2

    References

    • Takeya, Tetsuya; Doi, Hirohisa; Ogata, Tokutaro; Otsuka, Tsuyoshi; Okamoto, Iwao; Kotani, Eiichi Tetrahedron, 2004 , vol. 60, # 30 p. 6295 - 6310
  • Route3
    • 1-Methoxy-4-methylnaphthalene|CS-0504655
      24821-54-3
    • ~%
    • In-stock
      4-Methylnaphthalen-1-ol|CS-0444441
      10240-08-1

    References

    • The Plessey Company plc Patent: US4818096 A1, 1989 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   20.23
  • LogP   2.85382
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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