6-Methyl-5-(trifluoromethyl)pyridin-2-amine

Name: 6-Methyl-5-(trifluoromethyl)pyridin-2-amine
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CAS No. 1023813-33-3
Cat. No. CS-0439934
Molecule weight176.14
Purity≥96%
MDL No.MFCD09881222

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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6-Methyl-5-(trifluoromethyl)pyridin-2-amine|CS-0439934

Structure of 1023813-33-3

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General Information

CAS No. 1023813-33-3
Cat. No. CS-0439934
Purity ≥96%
MDL No. MFCD09881222
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₇F₃N₂
Molecular Weight 176.14
Synonym(s) 6-Methyl-5-trifluoromethyl-pyridin-2-ylamine
SMILES CC1=NC(=CC=C1C(F)(F)F)N

Description

6-Methyl-5-(trifluoromethyl)pyridin-2-amine features a trifluoromethyl group that imparts enhanced electron-withdrawal and metabolic stability, while the methyl substituent fine-tunes electronic properties. This pyridine scaffold serves as a key building block in medicinal chemistry, particularly for kinase inhibitors and bioactive heterocycles.

Application

6-Methyl-5-(trifluoromethyl)pyridin-2-amine serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles through palladium-catalyzed cross-coupling and electrophilic substitution reactions. Its electron-deficient pyridine core exhibits favorable reactivity in C–H functionalization and Suzuki-Miyaura coupling, while the methyl and trifluoromethyl groups provide steric and electronic modulation. The compound demonstrates bench stability and compatibility with standard purification protocols, facilitating integration into multi-step synthetic sequences for drug discovery applications.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

TPSA 38.91
LogP 1.99102
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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6-Methyl-5-(trifluoromethyl)pyridin-2-amine

CAS No. 1023813-33-3

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