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CS-W001157 4
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4-Amino-3-fluoro-2-methylphenol

  • CAS No. 1020173-27-6

  • Cat. No. CS-0509250
  • Molecule weight141.14
  • Purity≥98%
  • MDL No.MFCD19207913

*For research and further manufacturing use only, not for direct human use.

4-Amino-3-fluoro-2-methylphenol|CS-0509250

Structure of 1020173-27-6

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General Information

  • CAS No. 1020173-27-6
  • Cat. No. CS-0509250
  • Purity ≥98%
  • MDL No. MFCD19207913
  • Storage 4°C, protect from light, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₈FNO
  • Molecular Weight 141.14
  • Synonym(s) None
  • SMILES OC1=CC=C(N)C(F)=C1C

Description

4-Amino-3-fluoro-2-methylphenol features a strategically positioned amino group adjacent to a fluorine substituent, enabling enhanced electron donation and directed reactivity. The ortho-methyl group provides steric stabilization, while the phenolic hydroxyl offers a handle for derivatization. This scaffold combines electronic tuning with bench-stable handling, making it valuable in medicinal chemistry and agrochemical synthesis.

Application

4-Amino-3-fluoro-2-methylphenol serves as a versatile building block in medicinal chemistry, enabling the synthesis of fluorinated heterocycles and bioactive scaffolds. Its ortho-directed reactivity facilitates efficient functionalization, while the amino and phenolic groups offer complementary handles for derivatization. Bench-stable and readily purified, it functions effectively in standard coupling and cyclization protocols.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   46.25
  • LogP   1.42192
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   0

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