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(7-Methyl-[1,2,4]triazolo[4,3-a]pyridin-3-yl)methanamine

  • CAS No. 1020033-70-8

  • Cat. No. CS-0036736
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(7-Methyl-[1,2,4]triazolo[4,3-a]pyridin-3-yl)methanamine|CS-0036736

Structure of 1020033-70-8

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General Information

  • CAS No. 1020033-70-8
  • Cat. No. CS-0036736
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₀N₄
  • Molecular Weight 162.19
  • Synonym(s) C-(7-Methyl-[1,2,4]Triazolo[4,3-A]Pyridin-3-Yl)-Methylamine(WX603038)
  • SMILES CC1=CC2=NN=C(CN)N2C=C1

Description

This bench-stable, moisture-tolerant amine features a fused triazolopyridine core that enhances electronic delocalization and improves solubility in polar solvents. The 7-methyl substitution provides steric shielding, reducing undesired side reactions during coupling processes. This scaffold integrates readily into bioactive molecules, serving as a key building block for kinase inhibitors and pharmaceutical intermediates.

Application

(7-Methyl-[1,2,4]triazolo[4,3-a]pyridin-3-yl)methanamine serves as a versatile heterocyclic building block in medicinal chemistry, enabling the construction of bioactive scaffolds through facile functionalization at the amine terminus. The triazolopyridine core exhibits robust bench stability and compatibility with standard coupling reactions, facilitating rapid diversification for target-oriented synthesis. Its moderate basicity and defined polarity support efficient purification and integration into complex molecular architectures.

Safety Information

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GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 3259
Class : 8
Packing Group : Ⅲ
Hazard Statements : H314
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   56.21
  • LogP   0.49642
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   1

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