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CS-W001157 4
Total: USD 88.00

2-(Difluoromethyl)benzyl alcohol

  • CAS No. 1018678-49-3

  • Cat. No. CS-W000093
  • Purity≥96%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-(Difluoromethyl)benzyl alcohol|CS-W000093

Structure of 1018678-49-3

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General Information

  • CAS No. 1018678-49-3
  • Cat. No. CS-W000093
  • Purity ≥96%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₈F₂O
  • Molecular Weight 158.15
  • Synonym(s) (2-(Difluoromethyl)phenyl)methanol
  • SMILES OCc1ccccc1C(F)F

Description

2-(Difluoromethyl)benzyl alcohol features a difluoromethyl group directly attached to a benzyl scaffold, delivering enhanced metabolic stability and lipophilicity. This structural motif integrates readily into bioactive molecules, serving as a valuable building block in medicinal chemistry for modulating pharmacokinetic properties.

Application

2-(Difluoromethyl)benzyl alcohol serves as a versatile building block for fluorinated aromatic systems, enabling efficient access to bioactive scaffolds through standard functional group interconversions. Its bench-stable nature and tolerance to common reaction conditions facilitate downstream transformations such as oxidation to the carboxylic acid, reduction to the aldehyde, or incorporation into heterocycles via coupling reactions. The difluoromethyl group imparts enhanced metabolic stability and modulates electronic properties, making it valuable in medicinal chemistry and agrochemical development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   20.23
  • LogP   2.1165
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   2

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