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CS-W001157 4
Total: USD 88.00

[(2,6-difluorophenyl)carbamoyl]formic acid

  • CAS No. 1018295-42-5

  • Cat. No. CS-0215916
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

[(2,6-difluorophenyl)carbamoyl]formic acid|CS-0215916

Structure of 1018295-42-5

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General Information

  • CAS No. 1018295-42-5
  • Cat. No. CS-0215916
  • Purity ≥95%
  • MDL No. None
  • Storage 4°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₅F₂NO₃
  • Molecular Weight 201.13
  • Synonym(s) 2-((2,6-Difluorophenyl)amino)-2-oxoacetic acid
  • SMILES C1=CC(=C(C(=C1)F)NC(=O)C(=O)O)F

Description

This difluorophenylcarbamoylformic acid delivers a potent electron-deficient carbonyl motif for conjugation and bioconjugate synthesis. The ortho-fluoro substitution enhances metabolic stability while maintaining solubility in polar solvents. Its reactive formyl group enables efficient coupling under mild conditions, making it ideal for site-specific labeling and probe development in chemical biology workflows.

Application

[(2,6-difluorophenyl)carbamoyl]formic acid serves as a versatile building block for bioactive heterocycles and peptide mimetics, enabling efficient incorporation of difluorinated aromatic motifs. Its formamidine functionality facilitates nucleophilic addition and cyclization reactions under mild conditions, offering robust stability and ease of purification. The molecule functions effectively in solid-phase synthesis and supports orthogonal functional group handling, making it suitable for medicinal chemistry campaigns requiring enhanced metabolic stability and membrane permeability.

Safety Information

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GHS Pictogram :
GHS No : GHS07,GHS08,GHS09
Signal Word : Danger
UN#: 3077
Class : 9
Packing Group : Ⅲ
Hazard Statements : H302-H372-H411
Precautionary Statements : P260-P264-P273-P391-P501

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Computational Chemistry Data

  • TPSA   66.4
  • LogP   0.9879
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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