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CS-W001157 4
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4-(4-Bromothiazol-2-yl)morpholine

  • CAS No. 1017781-60-0

  • Cat. No. CS-0054862
  • Purity≥97%
  • MDL No.MFCD09607696
  • HazMat Fee +

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    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

4-(4-Bromothiazol-2-yl)morpholine|CS-0054862

Structure of 1017781-60-0

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Description

4-(4-Bromothiazol-2-yl)morpholine features a brominated thiazole moiety linked to a morpholine ring, delivering a potent electrophilic handle for cross-coupling reactions. This bench-stable, moisture-tolerant building block integrates seamlessly into medicinal chemistry programs requiring heteroaryl-functionalized scaffolds.

Application

4-(4-Bromothiazol-2-yl)morpholine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions for the construction of thiazole-containing pharmaceutical scaffolds. The bromo group exhibits high reactivity in Suzuki, Stille, and Negishi couplings, while the morpholine moiety provides solubility and hydrogen-bonding capacity. Bench-stable and readily purified by flash chromatography, it functions efficiently in late-stage functionalization and API synthesis.

General Information

  • CAS No. 1017781-60-0
  • Cat. No. CS-0054862
  • Purity ≥97%
  • MDL No. MFCD09607696
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₉BrN₂OS
  • Molecular Weight 249.13
  • Synonym(s) 4-(4-Bromo-1,3-thiazol-2-yl)morpholine
  • SMILES BrC1=CSC(N2CCOCC2)=N1

Computational Chemistry Data

  • TPSA   25.36
  • LogP   1.7422
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group :
Hazard Statements : H301
Precautionary Statements : P264-P270-P330-P405-P501

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