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CS-W001157 4
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ert-Butyl 3-[(methylamino)methyl]piperidine-1-carboxylate

  • CAS No. 1017356-25-0

  • Cat. No. CS-0028253
  • Purity≥97%
  • MDL No.MFCD08061952

*For research and further manufacturing use only, not for direct human use.

ert-Butyl 3-[(methylamino)methyl]piperidine-1-carboxylate|CS-0028253

Structure of 1017356-25-0

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General Information

  • CAS No. 1017356-25-0
  • Cat. No. CS-0028253
  • Purity ≥97%
  • MDL No. MFCD08061952
  • Storage RT, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₂₄N₂O₂
  • Molecular Weight 228.33
  • Synonym(s) Tert-butyl 3-((methylamino)methyl)piperidine-1-carboxylate
  • SMILES CC(C)(C)OC(N1CC(CCC1)CNC)=O

Description

1-Boc-3-((Methylamino)methyl)piperidine features a protected piperidine core with a methylaminoalkyl side chain, enabling direct incorporation into bioactive molecule scaffolds. The Boc group ensures stability during synthesis and facilitates selective deprotection under mild acidic conditions. This derivative offers enhanced solubility and compatibility in peptide and small-molecule drug development workflows.

Application

1-Boc-3-((methylamino)methyl)piperidine serves as a versatile building block in medicinal chemistry, enabling efficient access to piperidine-based scaffolds through mild deprotection and subsequent functionalization. The Boc group provides excellent bench stability and facilitates straightforward purification, while the pendant (methylamino)methyl moiety offers a reactive handle for further diversification via alkylation or reductive amination. This intermediate is particularly useful in the synthesis of bioactive molecules requiring nitrogen-rich heterocycles with defined stereochemistry and enhanced solubility.

Safety Information

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GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301
Precautionary Statements : P264-P270-P330-P405-P501

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Computational Chemistry Data

  • TPSA   41.57
  • LogP   1.8529
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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