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CS-W001157 4
Total: USD 88.00

1-(Quinolin-2-yl)ethanone

  • CAS No. 1011-47-8

  • Cat. No. CS-0155072
  • Purity≥98%
  • MDL No.MFCD08062664

*For research and further manufacturing use only, not for direct human use.

1-(Quinolin-2-yl)ethanone|CS-0155072

Structure of 1011-47-8

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General Information

  • CAS No. 1011-47-8
  • Cat. No. CS-0155072
  • Purity ≥98%
  • MDL No. MFCD08062664
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₉NO
  • Molecular Weight 171.20
  • Synonym(s) 1-quinolin-2-ylethanone
  • SMILES CC(=O)C1=NC2=C(C=CC=C2)C=C1

Description

1-(Quinolin-2-yl)ethanone features a quinoline scaffold linked to a ketone group, enabling integration into pharmaceutical intermediates and functional materials. This electron-deficient aryl ketone exhibits stability under standard conditions and facilitates efficient coupling reactions in synthetic workflows.

Application

1-(Quinolin-2-yl)ethanone serves as a versatile building block in medicinal chemistry, enabling efficient access to quinoline-based scaffolds through standard functional group transformations. Its ketone functionality facilitates nucleophilic addition, reductive amination, and coupling reactions, while the quinoline core provides structural rigidity and π-stacking potential. Bench-stable and readily purified by recrystallization, it functions effectively in multi-step syntheses of bioactive compounds and heterocyclic intermediates.

Synthesis

  • Route1
    • null|null
      91-22-5
    • Pyruvic acid, ≥97%|CS-1268663
      127-17-3
    • ~12%
    • In-stock
      1-(Quinolin-2-yl)ethanone|CS-0155072
      1011-47-8

    References

    • UCL BUSINESS PLC; BIRKBECK COLLEGE; WAKSMAN, Gabriel; TABOR, Alethea; SAYER, James; WALLDEN, Karin Patent: WO2012/168733 A1, 2012 ; Location in patent: Page/Page column 89-90 ; WO 2012/168733 A1
  • Route2

    References

    • PROSIDION LIMITED Patent: WO2006/85118 A2, 2006 ; Location in patent: Page/Page column 20-21 ; WO 2006/085118 A2
  • Route3
    • In-stock
      2-Chloroquinoline|CS-W007458
      612-62-4
    • null|null
      74-88-4
    • ~14%
    • null|null
      91-63-4
    • In-stock
      1-(Quinolin-2-yl)ethanone|CS-0155072
      1011-47-8

    References

    • Miura, Masahiro; Akase, Fumiaki; Shinohara, Masato; Nomura, Masakatsu Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1987 , p. 1021 - 1026

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H320-H335
Precautionary Statements : P261-P280-P302+P352

Quality Control

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Computational Chemistry Data

  • TPSA   29.96
  • LogP   2.4374
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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