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CS-W001157 4
Total: USD 88.00

5-Bromo-2,6-dichloropyrimidin-4-amine

  • CAS No. 101012-11-7

  • Cat. No. CS-0247019
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

5-Bromo-2,6-dichloropyrimidin-4-amine|CS-0247019

Structure of 101012-11-7

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General Information

  • CAS No. 101012-11-7
  • Cat. No. CS-0247019
  • Purity ≥98%
  • MDL No. None
  • Storage -20°C, sealed storage, away from moisture and light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₂BrCl₂N₃
  • Molecular Weight 242.89
  • Synonym(s) 5-bromo-2,6-dichloro-pyrimidin-4-ylamine
  • SMILES NC1=NC(Cl)=NC(Cl)=C1Br

Description

5-Bromo-2,6-dichloropyrimidin-4-amine serves as a critical heterocyclic building block in medicinal chemistry and agrochemical synthesis. The molecule features a pyrimidine core substituted with bromo and dichloro groups at electron-deficient positions, enabling efficient coupling reactions. This combination imparts high reactivity in palladium-catalyzed cross-coupling processes, facilitating rapid access to complex molecular architectures. The compound exhibits bench-stable handling characteristics under standard conditions.

Application

5-Bromo-2,6-dichloropyrimidin-4-amine serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling efficient construction of pyrimidine-based scaffolds. Its reactive bromo and amino groups facilitate palladium-catalyzed cross-coupling and nucleophilic substitution reactions. The molecule exhibits excellent bench stability and compatibility with diverse functional groups, making it well-suited for modular synthesis workflows and scale-up applications.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   51.8
  • LogP   2.1281
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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