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CS-W001157 4
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N-Phenyl-3-(trifluoromethyl)aniline

  • CAS No. 101-23-5

  • Cat. No. CS-0156099
  • Molecule weight237.22
  • Purity≥98%
  • MDL No.MFCD00017998

*For research and further manufacturing use only, not for direct human use.

N-Phenyl-3-(trifluoromethyl)aniline|CS-0156099

Structure of 101-23-5

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General Information

  • CAS No. 101-23-5
  • Cat. No. CS-0156099
  • Purity ≥98%
  • MDL No. MFCD00017998
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₁₀F₃N
  • Molecular Weight 237.22
  • Synonym(s) NSC 50453
  • SMILES C1=CC=C(C=C1)NC2=CC=CC(=C2)C(F)(F)F

Description

N-Phenyl-3-(trifluoromethyl)aniline features a trifluoromethyl group at the meta position, imparting enhanced electron-withdrawing character and improved metabolic stability. This arylamine integrates readily into pharmaceutical intermediates and functional materials, offering robust performance under standard bench conditions.

Application

N-Phenyl-3-(trifluoromethyl)aniline serves as a versatile building block in medicinal chemistry and materials science, leveraging the electron-withdrawing trifluoromethyl group to modulate electronic properties and metabolic stability. The aniline functionality enables direct coupling reactions and facilitates downstream functionalization via electrophilic substitution or transition-metal-catalyzed transformations. Its bench-stable nature and compatibility with common synthetic protocols make it well-suited for use in API development and heterocyclic scaffold construction.

Synthesis

  • Route1
    • null|null
      98-15-7
    • null|null
      74497-02-2
    • ~96%
    • In-stock
      N-Phenyl-3-(trifluoromethyl)aniline|CS-0156099
      101-23-5

    References

    • Journal of the American Chemical Society, , vol. 125, # 22 p. 6653 - 6655
  • Route2
    • null|null
      1198183-95-7
    • null|null
      98-16-8
    • ~83%
    • In-stock
      N-Phenyl-3-(trifluoromethyl)aniline|CS-0156099
      101-23-5

    References

    • Organic Letters, , vol. 13, # 7 p. 1784 - 1786
  • Route3
    • null|null
      66950-63-8
    • null|null
      98-16-8
    • ~84%
    • In-stock
      N-Phenyl-3-(trifluoromethyl)aniline|CS-0156099
      101-23-5

    References

    • Organic Letters, , vol. 13, # 7 p. 1784 - 1786

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H319-H413
Precautionary Statements : P264-P270-P273-P280-P330-P501

Quality Control

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Computational Chemistry Data

  • TPSA   12.03
  • LogP   4.449
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   2

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