4-Chloro-5-fluoronicotinonitrile

Name: 4-Chloro-5-fluoronicotinonitrile
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 1009334-65-9
Cat. No. CS-0130951
Purity≥97%
MDL No.MFCD13191767

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

4-Chloro-5-fluoronicotinonitrile|CS-0130951

Structure of 1009334-65-9

Size

Price

Quantity

* Please select Quantity before adding items.

General Information

CAS No. 1009334-65-9
Cat. No. CS-0130951
Purity ≥97%
MDL No. MFCD13191767
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₂ClFN₂
Molecular Weight 156.54
Synonym(s) 4-chloro-5-fluoropyridine-3-carbonitrile
SMILES N#CC1=C(Cl)C(F)=CN=C1

Description

4-Chloro-5-fluoronicotinonitrile features a strategically positioned nitrile group flanked by chlorine and fluorine substituents on a pyridine ring, delivering enhanced electron deficiency for use in cross-coupling reactions. This bench-stable compound integrates readily into complex heterocyclic architectures, enabling efficient access to advanced pharmaceutical intermediates under standard conditions.

Application

4-Chloro-5-fluoronicotinonitrile serves as a versatile building block in medicinal chemistry, enabling efficient construction of heterocyclic scaffolds via nucleophilic substitution and transition-metal-catalyzed coupling reactions. Its complementary halogen (Cl) and fluorine (F) substituents facilitate sequential functionalization, while the nitrile group provides a handle for derivatization. The compound exhibits good bench stability and is compatible with standard reaction conditions, making it valuable for rapid lead optimization and API intermediate synthesis.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS06
Signal Word : Danger	UN#: 2811
Class : 6.1	Packing Group : Ⅲ
Hazard Statements : H301-H311-H331
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

TPSA 36.68
LogP 1.74578
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Functional Group Cyanide/Nitrile

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

4-Chloro-5-fluoronicotinonitrile sigma4-Chloro-5-fluoronicotinonitrile manufacturer4-Chloro-5-fluoronicotinonitrile price4-Chloro-5-fluoronicotinonitrile structure4-Chloro-5-fluoronicotinonitrile SDSbuy 4-Chloro-5-fluoronicotinonitrile4-Chloro-5-fluoronicotinonitrile supplier4-Chloro-5-fluoronicotinonitrile uses4-Chloro-5-fluoronicotinonitrile molecular weightprice of 4-Chloro-5-fluoronicotinonitrile4-Chloro-5-fluoronicotinonitrile chemical name formula of 4-Chloro-5-fluoronicotinonitrile

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

4-Chloro-5-fluoronicotinonitrile

CAS No. 1009334-65-9

Recommended Products