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CS-W001157 4
Total: USD 88.00

5-(Trifluoromethyl)indole

  • CAS No. 100846-24-0

  • Cat. No. CS-W008231
  • Purity≥97%
  • MDL No.MFCD03095341

*For research and further manufacturing use only, not for direct human use.

5-(Trifluoromethyl)indole|CS-W008231

Structure of 100846-24-0

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General Information

  • CAS No. 100846-24-0
  • Cat. No. CS-W008231
  • Purity ≥97%
  • MDL No. MFCD03095341
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₆F₃N
  • Molecular Weight None
  • Synonym(s) 5-(Trifluoromethyl)-1H-indole
  • SMILES FC(C1=CC2=C(NC=C2)C=C1)(F)F

Description

Bis-PEG12-acid is a PEG linker containing two terminal carboxylic acid groups. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acids can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

Synthesis

  • Route1
    • null|null
      1217302-64-1
    • ~78%
    • In-stock
      5-(Trifluoromethyl)indole|CS-W008231
      100846-24-0

    References

    • KALYPSYS, INC.; BORCHARDT, Allen; DAVIS, Robert; BEAUREGARD, Clay; BECKER, Daniel; GAMACHE, Daniel; NOBLE, Stewart, A.; HELLBERG, Mark, R.; KLIMKO, Peter, G.; ZHIHAI, Qui; PAYNE, Joseph, E.; YANNI, John Patent: WO2011/112731 A2, 2011 ; Location in patent: Page/Page column 197-198 ; WO 2011/112731 A2
  • Route2

    References

    • Xu, Jun; Luo, Dong-Fen; Xiao, Bin; Liu, Zhao-Jing; Gong, Tian-Jun; Fu, Yao; Liu, Lei Chemical Communications, 2011 , vol. 47, # 14 p. 4300 - 4302
  • Route3
    • 3-Iodo-5-(trifluoromethyl)-1H-indole|CS-0745805
      440363-05-3
    • ~65%
    • In-stock
      5-(Trifluoromethyl)indole|CS-W008231
      100846-24-0

    References

    • Parmentier, Jean-Gilles; Poissonnet, Guillaume; Goldstein, Solo Heterocycles, 2002 , vol. 57, # 3 p. 465 - 476

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H300-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   15.79
  • LogP   3.1867
  • H_Acceptors   0
  • H_Donors   1
  • Rotatable_Bonds   0

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