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CS-W001157 4
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7-Bromo-1-methyl-2,3-dihydro-1H-indol-2-one

  • CAS No. 100831-25-2

  • Cat. No. CS-0055871
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

7-Bromo-1-methyl-2,3-dihydro-1H-indol-2-one|CS-0055871

Structure of 100831-25-2

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General Information

  • CAS No. 100831-25-2
  • Cat. No. CS-0055871
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₈BrNO
  • Molecular Weight 226.07
  • Synonym(s) None
  • SMILES O=C1N(C)C2=C(C=CC=C2Br)C1

Description

7-Bromo-1-methyl-2,3-dihydro-1H-indol-2-one is a bench-stable heterocyclic scaffold featuring a brominated indolinone core. This electron-deficient system integrates seamlessly into transition-metal-catalyzed coupling reactions, enabling rapid access to complex molecular architectures in medicinal chemistry and materials science applications.

Application

7-Bromo-1-methyl-2,3-dihydro-1H-indol-2-one serves as a versatile building block in medicinal chemistry, enabling efficient access to substituted indole scaffolds via palladium-catalyzed cross-coupling reactions. The bromine at C7 provides a reliable handle for further functionalization, while the 1-methyl substituent enhances stability and modulates electronic properties. Its bench-stable nature and compatibility with standard reaction conditions facilitate straightforward incorporation into complex molecular architectures.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362+P364

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Computational Chemistry Data

  • TPSA   20.31
  • LogP   1.968
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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