4-Chloro-1H-pyrazolo[3,4-d]pyrimidin-6-amine

Name: 4-Chloro-1H-pyrazolo[3,4-d]pyrimidin-6-amine
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 100644-65-3
Cat. No. CS-W003451
Purity≥95%
MDL No.MFCD08059805

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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4-Chloro-1H-pyrazolo[3,4-d]pyrimidin-6-amine|CS-W003451

Structure of 100644-65-3

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Description

4-Chloro-1H-pyrazolo[3,4-d]pyrimidin-6-amine serves as a critical heterocyclic scaffold in medicinal chemistry, featuring a chlorine atom at the 4-position and an amine group at C6. This configuration enables direct incorporation into kinase inhibitors and antiviral agents, where its electron-deficient core enhances target binding affinity. The compound exhibits bench-stable handling characteristics and compatibility with standard coupling reactions.

Application

4-Chloro-1H-pyrazolo[3,4-d]pyrimidin-6-amine serves as a versatile building block for the synthesis of bioactive heterocycles, enabling efficient access to pyrazolopyrimidine scaffolds prevalent in kinase inhibitors and antiviral agents. The chloro group facilitates nucleophilic substitution reactions, while the amine functionality supports derivatization via coupling protocols. Bench-stable and readily purified by recrystallization, it functions reliably in standard medicinal chemistry workflows.

General Information

CAS No. 100644-65-3
Cat. No. CS-W003451
Purity ≥95%
MDL No. MFCD08059805
Storage -20°C, sealed storage, away from moisture and light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₄ClN₅
Molecular Weight 169.57
Synonym(s) o[3,4-d]pyrimidin-6-amine
SMILES NC1=NC(Cl)=C2C(NN=C2)=N1

Computational Chemistry Data

TPSA 80.48
LogP 0.5885
H_Acceptors 4
H_Donors 2
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Pyrazole compounds

Building Blocks Skeleton Aromatic heterocycle compounds Pyrimidine compounds

Key Words

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4-Chloro-1H-pyrazolo[3,4-d]pyrimidin-6-amine

CAS No. 100644-65-3

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