Lot numbers can be found on the outside label of a product:
N-Methoxy-N-methylpyridine-4-carboxamide
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CAS No. 100377-32-0
- Cat. No. CS-0123032
- Purity≥98%
- MDL No.MFCD03837728
*For research and further manufacturing use only, not for direct human use.
Structure of 100377-32-0
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General Information
- CAS No. 100377-32-0
- Cat. No. CS-0123032
- Purity ≥98%
- MDL No. MFCD03837728
- Storage Store at room temperature
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₈H₁₀N₂O₂
- Molecular Weight 166.18
- Synonym(s) N-Methoxy-N-methylisonicotinamide
- SMILES O=C(C1=CC=NC=C1)N(OC)C
Description
N-Methoxy-N-methylpyridine-4-carboxamide features a pyridine-4-carboxamide core with orthogonal N-methoxy and N-methyl groups, enabling selective reactivity in amidation and coupling processes. This bench-stable derivative delivers efficient amide bond formation under mild conditions, offering enhanced solubility and reduced side reactions compared to traditional acylating agents.
Application
N-Methoxy-N-methylpyridine-4-carboxamide serves as a versatile acyl transfer reagent in peptide synthesis and small molecule derivatization. Its pyridine-4-carboxamide core enables efficient coupling with carboxylic acids under mild conditions, while the N-methoxy-N-methyl group enhances electrophilicity and facilitates clean reaction progress. The compound exhibits good bench stability, ease of handling, and compatibility with diverse functional groups, making it a reliable choice for iterative synthetic sequences and API intermediate construction.
Synthesis
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Route1
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55-22-1 -
In-stock
6638-79-5 - ~83%
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In-stock
100377-32-0
References
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Aventis Pharmaceuticals, Inc.; Hoechst Marion Roussel Deutschland GmbH Patent: EP1734037 A2, 2006 ; Location in patent: Page/Page column 17; 62 ;
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Route2
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55-22-1
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1117-97-1 - ~54%
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In-stock
100377-32-0
References
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ENVIVO PHARMACEUTICALS, INC. Patent: WO2009/158393 A1, 2009 ; Location in patent: Page/Page column 117 ;
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Route3
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55-22-1
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In-stock
6638-79-5
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530-62-1
- ~60%
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In-stock
100377-32-0
References
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Aventis Pharmaceuticals Inc.; Aventis Pharma Deutschland GmbH Patent: US2005/261341 A1, 2005 ;
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302
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Precautionary Statements : P264-P270-P330-P501
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Quality Control
Computational Chemistry Data
- TPSA 42.43
- LogP 0.715
- H_Acceptors 3
- H_Donors 0
- Rotatable_Bonds 2
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Key Words
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