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2-Amino-5-fluoropyridin-3-ol

  • CAS No. 1003711-04-3

  • Cat. No. CS-0130932
  • Purity≥97%
  • MDL No.MFCD09835240

*For research and further manufacturing use only, not for direct human use.

2-Amino-5-fluoropyridin-3-ol|CS-0130932

Structure of 1003711-04-3

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General Information

  • CAS No. 1003711-04-3
  • Cat. No. CS-0130932
  • Purity ≥97%
  • MDL No. MFCD09835240
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₅FN₂O
  • Molecular Weight 128.10
  • Synonym(s) 2-AMINO-5-FLUORO-3-HYDROXYPYRIDINE
  • SMILES OC1=CC(F)=CN=C1N

Description

2-Amino-5-fluoropyridin-3-ol features a strategically positioned amino group and fluorine atom on a pyridinol scaffold, enabling strong hydrogen bonding and enhanced metabolic stability. This electron-deficient heterocycle integrates readily into bioactive scaffolds, particularly in kinase inhibitors and pharmaceutical intermediates, where its dual functionalization supports efficient derivatization under standard conditions.

Application

2-Amino-5-fluoropyridin-3-ol serves as a versatile building block in medicinal chemistry, enabling efficient access to fluorinated heterocyclic scaffolds. Its ortho-amino and hydroxyl groups facilitate diverse coupling reactions and metal-catalyzed transformations, while the fluorine substituent enhances metabolic stability and modulates electronic properties. The compound exhibits good bench stability and is compatible with standard purification protocols, making it well-suited for iterative synthesis campaigns in API development.

Safety Information

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GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 3259
Class : 8
Packing Group : Ⅲ
Hazard Statements : H302-H318
Precautionary Statements : P264-P270-P280-P330-P501

Quality Control

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Computational Chemistry Data

  • TPSA   59.14
  • LogP   0.5085
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   0

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