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CS-W001157 4
Total: USD 88.00

3-Fluoro-4-iodobenzaldehyde

  • CAS No. 1003709-57-6

  • Cat. No. CS-W021917
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

3-Fluoro-4-iodobenzaldehyde|CS-W021917

Structure of 1003709-57-6

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General Information

  • CAS No. 1003709-57-6
  • Cat. No. CS-W021917
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C, protect from light, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₄FIO
  • Molecular Weight 250.01
  • Synonym(s) 3-fluoranyl-4-iodanyl-benzaldehyde
  • SMILES O=CC1=CC=C(I)C(F)=C1

Description

3-Fluoro-4-iodobenzaldehyde features a fluorinated aromatic ring paired with iodine and aldehyde functionalities, enabling direct coupling in cross-coupling reactions. The electron-deficient benzaldehyde moiety facilitates nucleophilic addition, while the ortho-fluoro group enhances regioselectivity in Pd-catalyzed transformations. This bench-stable compound serves as a key intermediate for pharmaceutical and agrochemical synthesis.

Application

3-Fluoro-4-iodobenzaldehyde serves as a versatile building block in transition-metal-catalyzed cross-coupling reactions, enabling efficient construction of biaryl and heteroaryl scaffolds. The ortho-fluoro and para-iodo substituents provide orthogonal reactivity for sequential functionalization, while the aldehyde group offers direct access to imines, oximes, and other downstream derivatives. Bench-stable and compatible with standard reaction conditions, it facilitates streamlined synthesis in medicinal chemistry and materials science applications.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   17.07
  • LogP   2.2428
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   1

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