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CS-W001157 4
Total: USD 88.00

5-Benzofurancarboxaldehyde

  • CAS No. 10035-16-2

  • Cat. No. CS-W008821
  • Purity≥95%
  • MDL No.MFCD03411182

*For research and further manufacturing use only, not for direct human use.

5-Benzofurancarboxaldehyde|CS-W008821

Structure of 10035-16-2

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General Information

  • CAS No. 10035-16-2
  • Cat. No. CS-W008821
  • Purity ≥95%
  • MDL No. MFCD03411182
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₆O₂
  • Molecular Weight None
  • Synonym(s) 1-Benzofuran-5-carbaldehyde
  • SMILES O=CC1=CC=C(OC=C2)C2=C1

Description

5-Benzofurancarboxaldehyde features a fused benzofuran core with an aldehyde group at the 5-position, delivering high reactivity in coupling and cyclization reactions. This electron-deficient heterocycle integrates readily into complex scaffolds under standard conditions.

Application

5-Benzofurancarboxaldehyde serves as a versatile building block in synthetic organic chemistry, enabling efficient construction of heterocyclic scaffolds and functionalized aromatic systems. Its aldehyde functionality facilitates nucleophilic additions, Wittig reactions, and coupling processes under standard conditions. The benzofuran core imparts stability and favorable electronic properties, making it suitable for applications in medicinal chemistry and materials science. Bench-stable and readily purified, it functions reliably in multi-step syntheses.

Synthesis

  • Route1

    References

    • Saitoh, Morihisa; Kunitomo, Jun; Kimura, Eiji; Iwashita, Hiroki; Uno, Yumiko; Onishi, Tomohiro; Uchiyama, Noriko; Kawamoto, Tomohiro; Tanaka, Toshimasa; Mol, Clifford D.; Dougan, Douglas R.; Textor, Garret P.; Snell, Gyorgy P.; Takizawa, Masayuki; Itoh, Fumio; Kori, Masakuni Journal of Medicinal Chemistry, 2009 , vol. 52, # 20 p. 6270 - 6286
  • Route2

    References

    • WYETH Patent: WO2009/76571 A1, 2009 ; Location in patent: Page/Page column 41 ; WO 2009/076571 A1
  • Route3
    • null|null
      68-12-2
    • ~65%
    • In-stock
      5-Benzofurancarboxaldehyde|CS-W008821
      10035-16-2

    References

    • Schering Corporation and Pharmacopeia, Inc. Patent: US2004/147559 A1, 2004 ; Location in patent: Page 122 ; US 20040147559 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   30.21
  • LogP   2.2453
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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