3-Amino-1-hydroxypyrrolidin-2-one

Name: 3-Amino-1-hydroxypyrrolidin-2-one
Brand: ChemScene
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CAS No. 1003-51-6
Cat. No. CS-0200048
Purity≥97%
MDL No.MFCD00069208

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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3-Amino-1-hydroxypyrrolidin-2-one|CS-0200048

Structure of 1003-51-6

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General Information

CAS No. 1003-51-6
Cat. No. CS-0200048
Purity ≥97%
MDL No. MFCD00069208
Storage 4°C, sealed storage, away from moisture and light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₄H₈N₂O₂
Molecular Weight 116.12
Synonym(s) HA966-001
SMILES C1CN(C(=O)C1N)O

Description

3-Amino-1-hydroxypyrrolidin-2-one features a unique combination of amino and hydroxyl functionalities within a pyrrolidinone scaffold, enabling robust hydrogen bonding and enhanced solubility. This polar, bench-stable heterocycle serves as a key building block in bioactive molecule synthesis, particularly in peptidomimetic and kinase inhibitor design.

Application

3-Amino-1-hydroxypyrrolidin-2-one serves as a versatile scaffold for the synthesis of bioactive heterocycles and peptide mimetics. Its amine and hydroxyl groups enable straightforward derivatization, while the pyrrolidinone core provides structural rigidity and favorable solubility. The compound exhibits good bench stability and compatibility with standard coupling protocols, facilitating efficient incorporation into complex molecular architectures.

Synthesis

Route1
- 1363373-26-5
- ~86%
- In-stock
  
  1003-51-6
References
- DUKE UNIVERSITY; ZHOU, Pei; TOONE, Eric, J. Patent: WO2012/31298 A2, 2012 ; Location in patent: Page/Page column 47 ; WO 2012/031298 A2

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P260-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 66.56
LogP -1.0648
H_Acceptors 3
H_Donors 2
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Alcohol

Building Blocks Skeleton Aliphatic heterocycle compounds Pyrrolidine compounds

Key Words

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3-Amino-1-hydroxypyrrolidin-2-one

CAS No. 1003-51-6

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