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CS-W001157 4
Total: USD 88.00

Isothiazolinone

  • CAS No. 1003-07-2

  • Cat. No. CS-0005502
  • Purity≥97%
  • MDL No.MFCD09834764

*For research and further manufacturing use only, not for direct human use.

Isothiazolinone|CS-0005502

Structure of 1003-07-2

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General Information

  • CAS No. 1003-07-2
  • Cat. No. CS-0005502
  • Purity ≥97%
  • MDL No. MFCD09834764
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₃H₃NOS
  • Molecular Weight 101.13
  • Synonym(s) Isothiazolin-3-one; 3(2H)-Isothiazolone
  • SMILES O=C1NSC=C1

Description

Isothiazolinone is a potent biocide featuring a heterocyclic thiazoline core that delivers broad-spectrum antimicrobial activity. This stable, moisture-tolerant compound resists degradation under standard conditions and integrates effectively into water-based formulations. It provides long-term preservation in industrial and consumer applications where microbial contamination poses a challenge.

Application

Isothiazolinone serves as a potent, broad-spectrum biocide in industrial and consumer applications. Its reactive thiazoline ring enables efficient microbial inhibition through irreversible protein alkylation. The compound exhibits excellent stability in aqueous formulations and functions effectively across a wide pH range. Ideal for preservative systems in paints, coatings, and personal care products, it provides reliable protection with low active concentrations.

Synthesis

  • Route1

    References

    • US2004/14776 A1, ; Page/Page column 37-38 ;
  • Route2
    • 3-[(3-Amino-3-oxopropyl)dithio]propanamide|CS-0034070
      1002-19-3
    • ~10%
    • In-stock
      5-Chloro-3-hydroxyisothiazole|CS-B1826
      25629-58-7
    • In-stock
      Isothiazolinone|CS-0005502
      1003-07-2

    References

    • Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 16 p. 2245 - 2252
  • Route3
    • null|null
      2807-36-5
    • null|null
      2682-21-5
    • ~%
    • null|null
      2682-36-2
    • In-stock
      Isothiazolinone|CS-0005502
      1003-07-2

    References

    • Journal of Organic Chemistry, , vol. 30, p. 2660 - 2665

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P264-P270-P330-P501

Quality Control

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Computational Chemistry Data

  • TPSA   32.86
  • LogP   0.4364
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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