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CS-W001157 4
Total: USD 88.00

2-(Bromomethyl)-6-fluoropyridine

  • CAS No. 100202-78-6

  • Cat. No. CS-W006122
  • Purity≥95%
  • MDL No.MFCD09953532

*For research and further manufacturing use only, not for direct human use.

2-(Bromomethyl)-6-fluoropyridine|CS-W006122

Structure of 100202-78-6

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General Information

  • CAS No. 100202-78-6
  • Cat. No. CS-W006122
  • Purity ≥95%
  • MDL No. MFCD09953532
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₅BrFN
  • Molecular Weight 190.01
  • Synonym(s) 6-(bromomethyl)-2-fluoropyridine
  • SMILES FC1=CC=CC(CBr)=N1

Description

2-(Bromomethyl)-6-fluoropyridine features a reactive bromomethyl group flanked by a fluorinated pyridine ring, enabling efficient coupling in cross-coupling and nucleophilic substitution reactions. The electron-deficient aromatic system enhances electrophilicity, while the bench-stable nature facilitates handling under standard conditions.

Application

2-(Bromomethyl)-6-fluoropyridine serves as a versatile synthetic building block for constructing fluorinated heterocycles and pharmaceutical intermediates. The bromomethyl group enables efficient nucleophilic substitution reactions, while the ortho-fluorine facilitates directed metalation or palladium-catalyzed coupling processes. Its bench-stable nature and compatibility with diverse functional groups make it ideal for multi-step synthesis in medicinal chemistry and process development workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 1760
Class : 8
Packing Group : Ⅲ
Hazard Statements : H302-H315-H318-H335
Precautionary Statements : P260-P264-P270-P271-P280-P301+P310-P302+P352-P304+P340-P305+P351+P338-P310-P312-P330-P332+P313-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   2.1156
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   1

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