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Structure of 1000934-03-1
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3-(Trifluoromethyl)piperidin-2-one features a sterically constrained piperidinone core bearing a strongly electron-withdrawing trifluoromethyl group, enhancing its metabolic stability and modulating electronic properties. This scaffold serves as a key building block in medicinal chemistry for targeted ligand design, particularly in CNS-directed therapeutics and kinase inhibitors.
3-(Trifluoromethyl)piperidin-2-one serves as a versatile building block in medicinal chemistry, enabling efficient access to bioactive heterocycles through standard amide bond formation and reductive amination. Its trifluoromethyl group enhances metabolic stability and lipophilicity, while the piperidinone core provides a rigid scaffold for structure-activity studies. The compound exhibits excellent bench stability and facilitates straightforward purification, making it well-suited for high-throughput synthesis and lead optimization workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: