Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

1-(3-Methoxypropyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

  • CAS No. 1000801-76-2

  • Cat. No. CS-W021222
  • Purity≥98%
  • MDL No.MFCD16659789

*For research and further manufacturing use only, not for direct human use.

1-(3-Methoxypropyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole|CS-W021222

Structure of 1000801-76-2

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 1000801-76-2
  • Cat. No. CS-W021222
  • Purity ≥98%
  • MDL No. MFCD16659789
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₂₃BN₂O₃
  • Molecular Weight 266.14
  • Synonym(s) (1-(3-METHOXYPROPYL)-1H-PYRAZOL-4-YL)BORONIC ACID PINACOL ESTER
  • SMILES COCCCN1C=C(C=N1)B1OC(C)(C)C(C)(C)O1

Description

This pyrazole derivative features a methoxypropyl group and a boronate ester moiety, enabling direct use in Suzuki-Miyaura cross-coupling reactions. The tetramethyl-substituted dioxaborolane enhances stability and reactivity under standard conditions, while the electron-rich pyrazole core facilitates efficient coupling with aryl halides. Designed for streamlined synthesis of complex heterocycles, this compound offers robust performance in diverse reaction environments.

Application

1-(3-Methoxypropyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole serves as a versatile boronate building block for Suzuki-Miyaura cross-coupling reactions. The pyrazole core provides metabolic stability and hydrogen-bonding capability, while the 3-methoxypropyl substituent enhances solubility and modulates lipophilicity. Bench-stable and compatible with diverse reaction conditions, it facilitates efficient construction of biaryl and heteroaryl scaffolds in medicinal chemistry and materials synthesis.

Synthesis

  • Route1
    • 4-Bromo-1-(3-methoxypropyl)-1h-pyrazole|CS-0257703
      1183903-41-4
    • In-stock
      Bis(pinacolato)diborane|CS-D1216
      73183-34-3
    • ~%
    • In-stock
      1-(3-Methoxypropyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole|CS-W021222
      1000801-76-2

    References

    • WO2010/129848 A2, ; Page/Page column 24-25 ; WO 2010/129848 A2

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   45.51
  • LogP   1.2188
  • H_Acceptors   5
  • H_Donors   0
  • Rotatable_Bonds   5

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 1000801-76-2 sigma1000801-76-2 manufacturer1000801-76-2 price1000801-76-2 structure1000801-76-2 SDSbuy 1000801-76-21000801-76-2 supplier1000801-76-2 uses1000801-76-2 molecular weightprice of 1000801-76-21000801-76-2 chemical name formula of 1000801-76-2
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label