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CS-W001157 4
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1-(tetrahydro-2H-pyran-2-yl)-1H-indazole-4-carboxylic acid

  • CAS No. 1000576-23-7

  • Cat. No. CS-0033969
  • Purity≥97%
  • MDL No.MFCD09870059

*For research and further manufacturing use only, not for direct human use.

1-(tetrahydro-2H-pyran-2-yl)-1H-indazole-4-carboxylic acid|CS-0033969

Structure of 1000576-23-7

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General Information

  • CAS No. 1000576-23-7
  • Cat. No. CS-0033969
  • Purity ≥97%
  • MDL No. MFCD09870059
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₁₄N₂O₃
  • Molecular Weight 246.26
  • Synonym(s) 4-Carboxy-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole, 2-(4-Carboxy-1H-indazol-1-yl)tetrahydro-2H-pyran
  • SMILES O=C(C1=CC=CC2=C1C=NN2C3CCCCO3)O

Description

This indazole carboxylic acid features a tetrahydropyran-2-yl protecting group that confers enhanced solubility and stability under standard conditions. The scaffold integrates a polar heterocyclic core with a robust, moisture-tolerant functionality suitable for synthetic intermediates in medicinal chemistry.

Application

1-(Tetrahydro-2H-pyran-2-yl)-1H-indazole-4-carboxylic acid serves as a versatile building block for indazole-based scaffolds, enabling direct incorporation into medicinal chemistry campaigns. The tetrahydropyranyl (THP) group provides robust protection of the carboxylic acid under standard reaction conditions, facilitating orthogonal functionalization and simplifying purification. This derivative exhibits excellent bench stability and compatibility with common coupling protocols, making it ideal for iterative synthesis of bioactive heterocycles and API intermediates.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   64.35
  • LogP   2.4336
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   2

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