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CS-W001157 4
Total: USD 88.00

6-Bromo-5-methyl-1H-indazole

  • CAS No. 1000343-69-0

  • Cat. No. CS-W019740
  • Purity≥96%
  • MDL No.MFCD09026997

*For research and further manufacturing use only, not for direct human use.

6-Bromo-5-methyl-1H-indazole|CS-W019740

Structure of 1000343-69-0

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General Information

  • CAS No. 1000343-69-0
  • Cat. No. CS-W019740
  • Purity ≥96%
  • MDL No. MFCD09026997
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₇BrN₂
  • Molecular Weight 211.06
  • Synonym(s) 7-(Methanesulfonyl)ethylsuccinimidyl
  • SMILES CC1=CC2=C(NN=C2)C=C1Br

Description

6-Bromo-5-methyl-1H-indazole is a heterocyclic scaffold featuring a bromine substituent at the 6-position and a methyl group at the 5-position, enabling selective functionalization in medicinal chemistry. This electron-deficient indazole core integrates readily into kinase inhibitors and bioactive molecules, offering enhanced metabolic stability and targeted binding affinity.

Application

6-Bromo-5-methyl-1H-indazole serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions for the construction of biaryl and heteroaryl scaffolds. The bromine atom facilitates efficient C–Br bond functionalization under standard conditions, while the methyl group enhances metabolic stability and modulates electronic properties. Its bench-stable nature and compatibility with diverse reaction conditions make it ideal for modular synthesis of targeted API candidates.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   28.68
  • LogP   2.63382
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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