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Cat.No. Product Name / Introduction Added
CS-0045 TPCA-1 August 2016
TPCA-1 is potent, selective inhibitor of IKK-2 (IC50 = 17.
 
CS-0047 IKK-3_Inhibitor August 2016
IKK-3 Inhibitor is a potent, selective, inhibitor of IKK-epsilon kinase with IC50 of 40 nM; inactive at IKK-α and IKK-β.
 
CS-0048 ITK_inhibitor August 2016
ITK inhibitor is a potent ITK inhibitor.
 
CS-0049 BMS-509744 August 2016
BMS-509744 is a cell-permeable aminothioaryl-thiazolo compound that potently inhibits ITK kinase activity (IC50 = 19 nM; [ATP] = 1 μM) in an ATP-competitive manner by stabilizing ITK activation loop in a substrate-blocking, inactive conformation, inhibiting Fyn, IR, Lck, Btk only at much higher concentrations (IC50 ≥1.
 
CS-0050 Tofacitinib August 2016
Tofacitinib(CP-690550) is a novel inhibitor of JAK3 with IC50 of 1 nM, 20- to 100-fold less potent against JAK2 and JAK1.
 
CS-0054 WHI-P97 August 2016
WHI-P97 is a rationally designed potent inhibitor of JAK-3.
 
CS-0057 A-770041 August 2016
A-770041 is selective and orally active Src-family Lck inhibitor; A-770041 is a 147 nM inhibitor of Lck (1 mM ATP) and is 300-fold selective against Fyn, the other Src family kinase involved in T-cell signaling.
 
CS-0072 SB_239063 August 2016
SB 239063 is a potent and selective p38 MAPK inhibitor (IC50 = 44 nM for p38α).
 
CS-0073 TAK-715 August 2016
TAK-715 is a p38 MAPK inhibitor for p38α with IC50 of 7.
 
CS-0074 VX-702 August 2016
VX-702 is a highly selective inhibitor of p38α MAPK(IC50=4 -20 nM), 14-fold higher potency against the p38α versus p38β.
 
CS-0090 Sotrastaurin August 2016
Sotrastaurin(AEB-071) is a potent and selective pan-PKC inhibitor, mostly for PKCθ with Ki of 0.
 
CS-0114 Fingolimod_(hydrochloride) August 2016
Fingolimod Hcl (FTY720) is a S1P antagonist with IC50 of 0.
 
CS-0140 SB_203580 August 2016
SB203580(RWJ 64809) is a p38 MAPK inhibitor with IC50 of 0.
 
CS-0195 VX-745 August 2016
VX-745 is a potent and selective inhibitor of p38α with IC50 of 10 nM, 22-fold greater selectivity versus p38β and no inhibition to p38γ.
 
CS-0205 Chelerythrine_Chloride August 2016
Chelerythrine is potent, cell-permeable inhibitor of protein kinase C (IC50 = 660 nM); competitive with respect to the phosphate acceptor and non-competitive with respect to ATP.
 
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CS-0645 Rimonabant
Rimonabant(SR141716) is a selective central cannabinoid (CB1) receptor inverse agonist with Ki of 1.
CS-2222 Meprednisone
Meprednisone is a glucocorticoid and a methylated derivative of prednisone.
CS-0264 DAPT
DAPT(GSI-IX) is an inhibitor of γ-secretase; DAPT causes a reduction in Aβ40 and Aβ42 levels in human primary neuronal cultures (IC50 values are 115 and 200 nM for total Aβ and Aβ42 respectively) and in brain extract, cerebrospinal fluid and plasma in vivo.
CS-0613 Tideglusib
Tideglusib(NP-031112) is an irreversible, non ATP-competitive GSK-3β inhibitor with IC50 of 60 nM.
CS-0757 SB-705498
SB-705498 is a potent, selective and orally bioavailable transient receptor potential vanilloid 1 (TRPV1) receptor antagonist with a pIC50 of 7.
CS-0766 Aripiprazole
Aripiprazole(Abilify) is a human 5-HT1A receptor partial agonist with a Ki of 4.
CS-1971 Haloperidol
Haloperidol blocks dopamine receptors in in the treatment of schizophrenia, acute psychosis, and delirium.
CS-0609 SCH 527123
SCH-527123 is a potent antagonist of both CXCR1 and CXCR2 with IC50 of 42 nM and 3 nM, respectively.
CS-0361 Boceprevir
Boceprevir(EBP-520, SCH503034) is an HCV protease inhibitor (Ki=14 nM) for the treatment of hepatitis C virus infection.
CS-0625 Avosentan
Avosentan(Ro 67-0565; SPP-301) is a potent, selective endothelin receptor(ETA receptor) antagonist.
CS-0494 XAV-939
XAV939 is a small molecule and selective Wnt pathway β-catenin-mediated transcription inhibitor and axin stabilizing agent with IC50 of 11 and 4 nM for the inhibition of TNKS1 and TNKS2, respectively.
CS-0592 YM-201636
YM201636 is a selective PIKfyve inhibitor with IC50 of 33 nM, less potent to p110α.
CS-0608 BMS-754807
BMS-754807 is a potent and reversible inhibitor of IGF-1R/InsR with IC50 of 1.
CS-0627 MEK162
MEK162(ARRY-438162; ARRY-162) is a potent inhibitor of MEK1/2 with IC50 of 12 nM.
CS-0765 CYT387 (sulfate salt)
CYT387 sulfate(momelotinib) is an ATP-competitive inhibitor of JAK1/JAK2 with IC50 of 11 nM/18 nM, ~10-fold selectivity versus JAK3.
CS-1955 CC-401
CC-401 is a second generation ATP-competitive anthrapyrazolone c-Jun N terminal kinase (JNK) inhibitor with potential antineoplastic activity.
CS-1956 XL413
XL413 is a potent and selective Cdc7 inhibitor with an IC50 of 3.
CS-B0575 1H-Pyrrolo[2,3-b]pyridin-4-amine, 1-methyl-
CS-B0576 1H-Pyrrolo[2,3-b]pyridine-1-carboxylic acid, 4-amino-, 1,1-dimethylethyl ester
CS-B0577 1H-Pyrrolo[2,3-b]pyridin-4-amine, 1-(phenylmethyl)-

 
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