Tel: 732-484-9848
Fax: 888-484-5008
Email: [email protected]
Building blocks
Bioactive molecules
Product Pathways
All Targets
Antibody-drug conjugate....
Biochemical Reagent
Cell Cycle/DNA Damage
GPCR/G protein
JAK/STAT Signaling
MAPK/ERK Pathway
Membrane Transporter/Io....
Metabolic Enzyme/Protease
Neuronal Signaling
Protein Tyrosine Kinase....
Stem Cells/Wnt
Vitamin D Related
Research Area
Cardiovascular Disease
Metabolic Disease
Neurological Disease
Product Type
All Products
New Products
Featured Products
Home   »   Product Pathways  »  PARP  »  XAV-939

Products are for research use only. Not for human use. We do not sell to patients.

CS-0494 XAV-939

(XAV939;NVP-XAV 939)
Structure Price and Availability of    XAV-939
United States
Size Price Stock
5mg $50 In-stock Inquiry
10mg $60 In-stock
50mg $180 In-stock
100mg $280 In-stock
200mg $500 In-stock
500 mg Get quote
1 g Get quote
 Distributor In Japan:  フナコシ株式会社    電話番号:81-3-5684-1620   
Inquiry for price and availability only. Please place your order via our email or fax.
Contact us for competitive discounts on bulk quantities .
  • Data Sheet
  • Introduction
  • References
  • Related Products

XAV-939  M.Wt:  312.31
XAV-939  Formula: C14H11F3N2OS
XAV-939  Solubility: DMSO:≥ 21.5 mg/mL
XAV-939  Purity: >98%
XAV-939  Storage:  Please store the product under the recommended conditions in the Certificate of Analysis.
CAS: 284028-89-3

View current batch:

XAV939 is a small molecule and selective Wnt pathway β-catenin-mediated transcription inhibitor and axin stabilizing agent with IC50 of 11 and 4 nM for the inhibition of TNKS1 and TNKS2, respectively. IC50 Value: 11 nM(TNKS1); 4 nM(TNKS2) Target: TMKS1/2; β-catenin in vitro: XAV-939 specifically inhibits tankyrase PARP activity. XAV-939 dramatically decreases DNA-PKcs protein levels, confirming the critical role of tankyrase poly-ADP-ribosylation activity in maintaining stability of the DNA-PKcs protein. The greatest reduction of DNA-PKcs protein levels (< 25% relative expression compared to DMSO treated controls) occurs at 12 hours with 1.0 μM XAV-939 exposure. Treatment of human lymphoblasts with 1.0 μM XAV-939 results in marked elevation of tankyrase 1 levels. XAV-939 is axin stabilizing agent. XAV-939 stimulates beta-catenin degradation by stabilizing axin, the concentration-limiting component of the destruction complex. XAV-939 stabilizes axin by blocking the poly-ADP-ribosylating enzymes tankyrase 1 and tankyrase 2. Both tankyrase isoforms interact with a highly conserved domain of axin and stimulate its degradation through the ubiquitin-proteasome pathway. XAV-939 deregulates the Wnt/b-catenin pathway which has been implicated in many cancers. in vivo: N/A

PARP  |   β-catenin  |  
Keywords: buy XAV-939 | XAV-939 Supplier | purchase XAV-939 | XAV-939 cost | XAV-939 manufacturer | order XAV-939 | XAV-939 distributor | XAV-939 structure,chemscene
buy 284028-89-3 | 284028-89-3 Supplier | purchase 284028-89-3 | 284028-89-3 cost | 284028-89-3 manufacturer | order 284028-89-3 | 284028-89-3 distributor | 284028-89-3 structure,chemscene

Tel: 732-484-9848
Fax: 888-484-5008
Email:  [email protected]
Address: 11 Deer Park Drive, Suite 102D Monmouth Junction, NJ 08852.
Products are for research use only. Not for human use. We do not sell to patients. Sitemap | Inhibitor © Copyright 2012. All Rights Reserved.