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Home   »   Product Pathways  »  Sirtuin  »  Salermide

Products are for research use only. Not for human use. We do not sell to patients.

CS-6203 Salermide

Structure Price and Availability of    Salermide
United States
Size Price Stock
5mg $50 In-stock Inquiry
10mg $70 In-stock
25mg $150 In-stock
50mg $260 In-stock
100mg $460 In-stock
200 mg Get quote
500 mg Get quote
 Distributor In Japan:  フナコシ株式会社    電話番号:81-3-5684-1620   
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Salermide  M.Wt:  394.47
Salermide  Formula: C26H22N2O2
Salermide  Solubility: 10 mM in DMSO
Salermide  Purity: >98%
Salermide  Storage:  Please store the product under the recommended conditions in the Certificate of Analysis.
CAS: 1105698-15-4

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Salermide is an inhibitor of Sirt1 and Sirt2; can cause strong cancer-specific apoptotic cell death. InVitro: Salermide shows a dose-dependent inhibition that rises to 80% at 90 μM and 25 μM against Sirt1 and Sirt2, respectively. Salermide can prompt tumour-specific cell death in a wide range of human cancer cell lines derived from leukaemia (MOLT4, KG1A, K562), lymphoma (Raji), colon (SW480) and breast (MDA-MB-231). Incubation with 100 μM Salermide alone resulted in an increase of cytosolicactivated caspase 3 and a decrease of mitochondrialcytochrome. Salermide alone can induce apoptosis through both extrinsic and intrinsic pathways. Salermide had several antitumorigenic advantages over the earlier described class III HDAC inhibitors: firstly, it mimics the universal proapoptotic effect on cancer samples exhibited by the classical class I, II and IV HDAC inhibitors, and secondly, its proapoptotic effect is cancer-specific[1]. InVivo: Salermide is well tolerated by mice at concentrations up to 100 μM. Salermide's mechanism of action in vivo is specifically mediated by Sirt1. Intraperitoneal feeding of Salermide has no apparent toxicity in nude mice[1].

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