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Home   »   Product Pathways  »  Wnt  »  PNU-74654

Products are for research use only. Not for human use. We do not sell to patients.

CS-6211 PNU-74654

(PNU74654;PNU 74654)
Structure Price and Availability of    PNU-74654
United States
Size Price Stock
5mg $70 In-stock Inquiry
10mg $120 In-stock
25mg $260 In-stock
50mg $460 In-stock
100 mg Get quote
200 mg Get quote
 Distributor In Japan:  フナコシ株式会社    電話番号:81-3-5684-1620   
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PNU-74654  M.Wt:  320.34
PNU-74654  Formula: C19H16N2O3
PNU-74654  Solubility: ≥30 mg/mL in DMSO
PNU-74654  Purity: >98%
PNU-74654  Storage:  Please store the product under the recommended conditions in the Certificate of Analysis.
CAS: 113906-27-7

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PNU-74654 is an inhibitor of Wnt/β-catenin pathway with an IC50 of 129.8 μM in NCI-H295 cell. IC50&Target: 129.8 μM (Wnt/β-catenin, NCI-H295 cell)[1] InVitro: PNU-74654 binds to β-catenin with a KD of 450 nM. The Tcf3/Tcf4-binding surface on β-catenin contains a well-defined hot spot around residues K435 and R469. The binding mode of PNU-74654 involves the two narrow pockets on either side of this hot spot[2]. In NCI-H295 cells,PNU-74654 significantly decreases cell proliferation 96 h after treatment, increases early and late apoptosis, decreases nuclear beta-catenin accumulation, impairs CTNNB1/beta-catenin expression and increases beta-catenin target genes 48 h after treatment. No effects are observed on HeLa cells. In NCI-H295 cells, PNU-74654 decreases cortisol, testosterone and androstenedione secretion 24 and 48 h after treatment. The SF1 and CYP21A2 mRNA expression as well as the protein levels of STAR and aldosterone synthase are decreased in NCI-H295 cells after 48 h PNU-74654 treatment. In Y1 cells, PNU-74654 impairs corticosterone secretion 24 h after treatment but did not decrease cell viability[1].

Wnt  |   β-catenin  |  
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