Tel: 732-484-9848
Fax: 888-484-5008
Email: [email protected]
   
Building blocks
Intermediates
Bioactive molecules
Product Pathways
All Targets
Anti-infection
Antibody-drug conjugate....
Apoptosis
Autophagy
Biochemical Reagent
Cell Cycle/DNA Damage
Cytoskeleton
Epigenetics
GPCR/G protein
Immunology/Inflammation
JAK/STAT Signaling
MAPK/ERK Pathway
Membrane Transporter/Io....
Metabolic Enzyme/Protease
Neuronal Signaling
NF-κB
Others
PI3K/Akt/mTOR
Protein Tyrosine Kinase....
Stem Cells/Wnt
TGF-beta/Smad
Vitamin D Related
Research Area
Cancer
Cardiovascular Disease
Endocrinology
Infection
Metabolic Disease
Neurological Disease
Others
Inflammation/Immunology
Product Type
All Products
New Products
Featured Products
Home   »   Product Pathways  »  MEK  »  MEK162

Products are for research use only. Not for human use. We do not sell to patients.


CS-0627 MEK162


(Binimetinib;ARRY-162;ARRY-438162;MEK 162;ARRY 162;ARRY 438162)
Structure Price and Availability of    MEK162
United States
Size Price Stock
10mg $60 In-stock Inquiry
50mg $140 In-stock
100mg $230 In-stock
200mg $330 In-stock
500 mg Get quote
1 g Get quote
 Distributor In Japan:  フナコシ株式会社 www.funakoshi.co.jp    電話番号:81-3-5684-1620   
 FAX番号:81-3-5684-1775
Inquiry for price and availability only. Please place your order via our email or fax.
Contact us for competitive discounts on bulk quantities .
  • Data Sheet
  • Introduction
  • References
  • Related Products

MEK162  M.Wt:  441.23
MEK162  Formula: C17H15BrF2N4O3
MEK162  Solubility: in DMSO > 10 mM
MEK162  Purity: >98%
MEK162  Storage:  Please store the product under the recommended conditions in the Certificate of Analysis.
CAS: 606143-89-9

View current batch:

MEK162(ARRY-438162; ARRY-162) is a potent inhibitor of MEK1/2 with IC50 of 12 nM. IC50 value: 12 nM [1] Target: MEK1/2 in vitro: ARRY-438162 (625 nM) inhibits in vitro osteoclast differentiation with IC50 of 39 nM. ARRY-438162 (10 μM) inhibits in vitro osteoclast resorption with IC50 of 625 nM. ARRY-438162 (2 μM) weakly affects osteoblast differentiation. [2] ARRY-438162 is a recently disclosed potent and selective ATP non-competitive MEK1/2 inhibitor, inhibits pERK in cells with an IC50 of11 nM. [3] MEK162 (1 μM) combined with MK-2206 (2 μM) completely reverses the resistance of RSK-expressing MCF7 cells. [4] in vivo: ARRY-438162 (10 mg/kg, po, bid) reduces disease severity in a dose-related manner in rat collagen-induced arthritis (CIA) and rat adjuvant-induced arthritis (AIA) models. ARRY-438162 (po, bid) inhibits increases in ankle diameter by 27% and 50% at 1 mg/kg and 3 mg/kg in the rat collagen-induced arthritis (CIA) model, while ibuprofen has 46% inhibition. ARRY-438162 (10 mg/kg, po, bid) significantly inhibits lesions (inflammation, cartilage damage, pannus formation and bone resorption) by 32% and 60% at 1 mg/kg and 3 mg/kg in the rat collagen-induced arthritis (CIA) model. ARRY-438162 inhibits AIA ankle diameter 11% and 34% at 3 mg/kg and 10 mg/kg in rat adjuvant-induced arthritis (AIA) models [1]. MEK162 (6 mg/kg, BID) combined with BEZ235 results in a significant reduction of tumor growth in immunodeficient mice injected with MCF7 cells [4].

MEK  |  
Keywords: buy MEK162 | MEK162 Supplier | purchase MEK162 | MEK162 cost | MEK162 manufacturer | order MEK162 | MEK162 distributor | MEK162 structure,chemscene
buy 606143-89-9 | 606143-89-9 Supplier | purchase 606143-89-9 | 606143-89-9 cost | 606143-89-9 manufacturer | order 606143-89-9 | 606143-89-9 distributor | 606143-89-9 structure,chemscene


CHEMSCENE, LLC
Tel: 732-484-9848
Fax: 888-484-5008
Email:  [email protected]
Address: 11 Deer Park Drive, Suite 102D Monmouth Junction, NJ 08852.
Products are for research use only. Not for human use. We do not sell to patients. Sitemap | Inhibitor © Copyright 2012. All Rights Reserved.