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Home   »   Product Pathways  »  MEK  »  MEK162

Products are for research use only. Not for human use. We do not sell to patients.

CS-0627 MEK162

(Binimetinib;ARRY-162;ARRY-438162;MEK 162;ARRY 162;ARRY 438162)
Structure Price and Availability of    MEK162
United States
Size Price Stock
10mg $60 In-stock Inquiry
50mg $140 In-stock
100mg $230 In-stock
200mg $330 In-stock
500 mg Get quote
1 g Get quote
 Distributor In Japan:  フナコシ株式会社    電話番号:81-3-5684-1620   
Inquiry for price and availability only. Please place your order via our email or fax.
Contact us for competitive discounts on bulk quantities .
  • Data Sheet
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MEK162  M.Wt:  441.23
MEK162  Formula: C17H15BrF2N4O3
MEK162  Solubility: in DMSO > 10 mM
MEK162  Purity: >98%
MEK162  Storage:  Please store the product under the recommended conditions in the Certificate of Analysis.
CAS: 606143-89-9

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MEK162(ARRY-438162; ARRY-162) is a potent inhibitor of MEK1/2 with IC50 of 12 nM. IC50 value: 12 nM [1] Target: MEK1/2 in vitro: ARRY-438162 (625 nM) inhibits in vitro osteoclast differentiation with IC50 of 39 nM. ARRY-438162 (10 μM) inhibits in vitro osteoclast resorption with IC50 of 625 nM. ARRY-438162 (2 μM) weakly affects osteoblast differentiation. [2] ARRY-438162 is a recently disclosed potent and selective ATP non-competitive MEK1/2 inhibitor, inhibits pERK in cells with an IC50 of11 nM. [3] MEK162 (1 μM) combined with MK-2206 (2 μM) completely reverses the resistance of RSK-expressing MCF7 cells. [4] in vivo: ARRY-438162 (10 mg/kg, po, bid) reduces disease severity in a dose-related manner in rat collagen-induced arthritis (CIA) and rat adjuvant-induced arthritis (AIA) models. ARRY-438162 (po, bid) inhibits increases in ankle diameter by 27% and 50% at 1 mg/kg and 3 mg/kg in the rat collagen-induced arthritis (CIA) model, while ibuprofen has 46% inhibition. ARRY-438162 (10 mg/kg, po, bid) significantly inhibits lesions (inflammation, cartilage damage, pannus formation and bone resorption) by 32% and 60% at 1 mg/kg and 3 mg/kg in the rat collagen-induced arthritis (CIA) model. ARRY-438162 inhibits AIA ankle diameter 11% and 34% at 3 mg/kg and 10 mg/kg in rat adjuvant-induced arthritis (AIA) models [1]. MEK162 (6 mg/kg, BID) combined with BEZ235 results in a significant reduction of tumor growth in immunodeficient mice injected with MCF7 cells [4].

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