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Home   »   Product Pathways  »  P-glycoprotein   »  HM30181

Products are for research use only. Not for human use. We do not sell to patients.


CS-6194 HM30181


(HM30181A)
Structure Price and Availability of    HM30181
United States
Size Price Stock
5mg $100 In-stock Inquiry
10mg $150 In-stock
50mg $420 In-stock
100mg $590 In-stock
200 mg Get quote
500 mg Get quote
 Distributor In Japan:  フナコシ株式会社 www.funakoshi.co.jp    電話番号:81-3-5684-1620   
 FAX番号:81-3-5684-1775
Inquiry for price and availability only. Please place your order via our email or fax.
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  • Data Sheet
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HM30181  M.Wt:  688.73
HM30181  Formula: C38H36N6O7
HM30181  Solubility: DMSO: ≤ 6.6 mg/mL
HM30181  Purity: >98%
HM30181  Storage:  Please store the product under the recommended conditions in the Certificate of Analysis.
CAS: 849675-66-7

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HM30181 is a potent and selective inhibitor of P-glycoprotein. InVitro: HM30181 is shown to be approximately equipotent with the reference Pgp inhibitor tariquidar in inhibiting rhodamine 123 efflux from CCRF-CEM T cells (IC50, tariquidar: 8.2±2.0 nM, HM30181: 13.1±2.3 nM) [1]. HM30181 shows a high selectivity for mP-gp and its potency is 20-50 times higher than that of tariquitar, another third generation P-gp inhibitor[2]. InVivo: PET scans with the Pgp substrate (R)-[ 11C]verapamil in FVB wild-type mice pretreated i.v. with HM30181 (10 or 21 mg/kg) failes to show significant increases in (R)-[ 11C]verapamil brain uptake compared with vehicle treated animals[1]. HM30181 inhibits P-gp mainly in the intestinal endothelium, which can be beneficial because pan-inhibition of P-gp, particularly in the brain, could lead to detrimental adverse events. HM30181 increases the oral bioavailability of co-administered paclitaxel by more than 12 times in rats[2].

P-glycoprotein   |  
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Products are for research use only. Not for human use. We do not sell to patients. Sitemap | Inhibitor © Copyright 2012. All Rights Reserved.