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Home   »   Product Pathways  »  Others  »  Glaucocalyxin B

Products are for research use only. Not for human use. We do not sell to patients.

CS-6208 Glaucocalyxin-B

Structure Price and Availability of    Glaucocalyxin-B
United States
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10mg $500 Backordered
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 Distributor In Japan:  フナコシ株式会社    電話番号:81-3-5684-1620   
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Glaucocalyxin-B  M.Wt:  374.47
Glaucocalyxin-B  Formula: C22H30O5
Glaucocalyxin-B  Solubility: in DMSO
Glaucocalyxin-B  Purity: >98%
Glaucocalyxin-B  Storage:  Please store the product under the recommended conditions in the Certificate of Analysis.
CAS: 80508-81-2

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Glaucocalyxin B is an ent kaurane diterpenoid isolated from the Chinese traditional medicine Rabdosia japonica with anticancer and antitumor activity; decreases the growth of HL-60 cells with an IC50 of approximately 5.86 μM at 24 h. IC50&Target: 5.86 μM (HL-60 cell Growth)[1] InVitro: Glaucocalyxin A (GlnA) and (GlnB) dose-dependently decrease the growth of HL-60 cells with an IC50 of approximately 6.15 and 5.86 μM at 24 h, respectively. Both Gln A and B could induce apoptosis, G2/M-phase cycle arrest, DNA damage and the accumulation of reactive oxygen species (ROS) in HL-60 cells[1]. GlnB inhibits the proliferation of human cervical cancer cells in vitro through the induction of apoptosis andautophagy, which may be mediated by the phosphatidylinositol 4,5 bisphosphate 3 kinase/Akt signaling pathway. Treatment with GlnB inhibits the proliferation of HeLa and SiHa cervical cancer cell lines in a dose dependent manner. GlnB increases the apoptotic cell population of and enhanced poly (ADP ribose) polymerase 1 cleavage. GlnB also induces increased light chain 3 II/I protein cleavage, indicating the induction of autophagy. GlnB treatment increases the expression of phosphatase and tensin homolog and decreases the expression of phosphorylated protein kinase B[2]. Glaucocalyxin B (GLB), one of five ent-kauranoid diterpenoids, significantly decreased the generation of nitric oxide (NO), tumor necrosis factor (TNF)-α, interleukin (IL)-1β, cyclooxygenase (COX)-2 and inducible nitric oxide synthase (iNOS) in the lipopolysaccharide (LPS)-activated microglia cells[3].

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