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Home   »   Product Pathways  »  Topoisomerase  »  Ellipticine hydrochloride

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CS-6199 Ellipticine-hydrochloride

Structure Price and Availability of    Ellipticine-hydrochloride
United States
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5mg $50 In-stock Inquiry
10mg $75 In-stock
50mg $310 In-stock
100mg $550 In-stock
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 Distributor In Japan:  フナコシ株式会社    電話番号:81-3-5684-1620   
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Ellipticine-hydrochloride  M.Wt:  282.77
Ellipticine-hydrochloride  Formula: C17H15ClN2
Ellipticine-hydrochloride  Solubility: ≤5.8 mg/mL
Ellipticine-hydrochloride  Purity: >98%
Ellipticine-hydrochloride  Storage:  Please store the product under the recommended conditions in the Certificate of Analysis.
CAS: 5081-48-1

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Ellipticine hydrochloride is a potent antineoplastic agent; inhibits DNA topoisomerase II activities. InVitro: Ellipticine is a potent antineoplastic agent exhibiting the multimodal mechanism of its action. The mechanisms of ellipticine antitumor, mutagenic and cytotoxic activities are suggested to be intercalation into DNA and inhibition of DNA topoisomerase II activity. Another mode of ellipticine action is the formation of covalent DNA adducts mediated by its oxidation with cytochromes P450 (CYP) and peroxidases[1]. Ellipticine can also act as an inhibitor or inducer of biotransformation enzymes, thereby modulating its own metabolism leading to its genotoxic and pharmacological effects. Treatment of cells with ellipticine results in inhibition of cell growth and proliferation. This effect is associated with formation of two covalent ellipticine-derived DNA adducts[2]. InVivo: Ellipticine treatment results in ellipticine-derived DNA adduct generation in several healthy organs (liver, kidney, lung, spleen, breast, heart and brain) and in DNA of mammary adenocarcinoma. The levels of ellipticine-derived DNA adducts generated in these adenocarcinomas are almost 2-fold higher than in normal healthy mammary tissue. The induced expression of cytochrome b5 protein in liver of rats treated with ellipticine suggests that cytochrome b5 may modulate the CYP-mediated bioactivation and detoxification of ellipticine[3].

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