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Home   »   Product Pathways  »  Histone Demethylase  »  DDP-38003 dihydrochloride

Products are for research use only. Not for human use. We do not sell to patients.


CS-6188 DDP-38003-dihydrochloride


(DDP 38003 dihydrochloride;DDP38003 dihydrochloride)
Structure Price and Availability of    DDP-38003-dihydrochloride
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CS-6188
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DDP-38003-dihydrochloride  M.Wt:  423.38
DDP-38003-dihydrochloride  Formula: C21H28Cl2N4O
DDP-38003-dihydrochloride  Solubility: in DMSO
DDP-38003-dihydrochloride  Purity: >98%
DDP-38003-dihydrochloride  Storage:  Please store the product under the recommended conditions in the Certificate of Analysis.
CAS: 1831167-98-6

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DDP-38003 dihydrochloride is an novel, orally available inhibitor of histone lysine-specific demethylase 1A (KDM1A/LSD1) with an IC50 of 84 nM. IC50&Target: 84 nM (KDM1A/LSD1)[1] InVitro: DDP-38003 inhibits KDM1A with an IC50 of 84 nM. DDP-38003 is more active in reducing the colony forming ability and in inducing thedifferentiation of THP-1 cells compared to the 1R, 2S analogue[1]. InVivo: DDP-38003 exhibits in vivo efficacy after oral administration, determining a 62% increased survival in mouse leukemia models with evidence of KDM1A inhibition. The half life of DDP-38003 is 8 h. A significant dose dependent increase of mice survival is obtained by DDP-38003 treatment. The survival rate increases 35% and 62% at the dose of 11.25 and 22.50 mg/kg, respectively. DDP-38003 is a potential oral anticancer agent[1].

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