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Home   »   Product Pathways  »  JAK  »  CYT387 (sulfate salt)

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CS-0765 CYT387_(sulfate_salt)

(CYT-387 sulfate;CYT 387 sulfate;momelotinib sulfate)
Structure Price and Availability of    CYT387_(sulfate_salt)
United States
Size Price Stock
5mg $80 In-stock Inquiry
10mg $105 In-stock
50mg $310 In-stock
100mg $535 In-stock
200 mg Get quote
500 mg Get quote
 Distributor In Japan:  フナコシ株式会社    電話番号:81-3-5684-1620   
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CYT387_(sulfate_salt)  M.Wt:  610.62
CYT387_(sulfate_salt)  Formula: C23H26N6O10S2
CYT387_(sulfate_salt)  Solubility: DMSO: ≥ 6.1 mg/mL
CYT387_(sulfate_salt)  Purity: >98%
CYT387_(sulfate_salt)  Storage:  Please store the product under the recommended conditions in the Certificate of Analysis.
CAS: 1056636-06-6

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CYT387 sulfate(momelotinib) is an ATP-competitive inhibitor of JAK1/JAK2 with IC50 of 11 nM/18 nM, ~10-fold selectivity versus JAK3. IC50 value: 11 nM/18 nM(JAK1/JAK2) [1] Target: JAK1/JAK2 in vitro: CYT387 inhibits the proliferation of parental Ba/F3 cells (Ba/F3-wt) stimulated by IL-3 with IC50 of 1400 nM. Furthermore, CYT387 also causes the inhibition of cell proliferation in cell lines constitutively activated by JAK2 or MPL signaling, including Ba/F3-MPLW515L cells, CHRF-288-11 cells and Ba/F3-TEL-JAK2 cells with IC50 of 200 nM, 1 nM and 700 nM, respectively. In addition, CYT387 has been shown to inhibit erythroid colony growth in vitro from JAK2V617F-positive PV patients with similar potency with IC50 of 2μ-4 μM [1]. A recent study shows that CYT387 inhibits PI3K/AKT and Ras/MAPK signaling induced by IL-6 and IGF-1. Moreover, CYT387 induces apoptosis as a single agent and synergizes with the conventional anti-MM therapies bortezomib and melphalan in primary multiple myeloma (MM) cells [2]. in vivo: In a murine MPN model, CYT387 normalizes white cell counts, hematocrit, spleen size, and restores physiologic levels of inflammatory cytokines [3].

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